| Author | Heimfarth, Luana | |
| Author | Anjos, Klécia Santos dos | |
| Author | Carvalho, Yasmim Maria Barbosa Gomes de | |
| Author | Santos, Bruno Lucena dos | |
| Author | Serafini, Mairim Russo | |
| Author | Carvalho Neto, Antônio Guilherme de | |
| Author | Nunes, Paula Santos | |
| Author | Beserra Filho, José Ivo Araújo | |
| Author | Silva, Sara Pereira da | |
| Author | Ribeiro, Alessandra Mussi | |
| Author | Bezerra, Daniel Pereira | |
| Author | Marreto, Ricardo Neves | |
| Author | Quintans, Jullyana de Souza Siqueira | |
| Author | Araújo, Adriano Antunes de Souza | |
| Author | Coutinho, Henrique Douglas Melo | |
| Author | Scotti, Marcus T. | |
| Author | Scotti, Luciana | |
| Author | Quintans Júnior, Lucindo José | |
| Access date | 2020-07-23T15:19:20Z | |
| Available date | 2020-07-23T15:19:20Z | |
| Document date | 2020 | |
| Citation | HEIMFARTH, Luana et al.Characterization of β-cyclodextrin/myrtenol complex and its protective effect against nociceptive behavior and cognitive impairment in a chronic musculoskeletal pain model. Carbohydrate Polymers, p. 1-12, 2020. | pt_BR |
| ISSN | 0144-8617 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/42361 | |
| Sponsorship | CNPq, FAPITEC/SE, CAPES and FINEP, all from Brazil. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Dor crônica | pt_BR |
| Subject in Portuguese | Fibromialgia | pt_BR |
| Subject in Portuguese | Myrtenol | pt_BR |
| Subject in Portuguese | Ciclodextrina | pt_BR |
| Subject in Portuguese | Estresse oxidativo | pt_BR |
| Title | Characterization of β-cyclodextrin/myrtenol complex and its protective effect against nociceptive behavior and cognitive impairment in a chronic musculoskeletal pain model | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.carbpol.2020.116448 | |
| Abstract | Myrtenol has gained wide interest because of its pharmacological profiles, mainly for treatment of chronic diseases. To improve the solubility of myrtenol, the formation of inclusion complexes with β-cyclodextrin was performed by physical mixture, kneading process or slurry complexation (SC) methods and characterized using thermal analysis, XRD, SEM and NMR. From these results, myrtenol complexed by SC was successfully complexed into β-cyclodextrin cavity. The interaction between myrtenol and β-cyclodextrin was confirmed by molecular docking. Hence, the SC β-cyclodextrin-myrtenol complex was evaluate for its anti-hyperalgesic, anxiolytic and antioxidant activity in a fibromyalgia model. Results show that myrtenol and β-cyclodextrin form a stable complex and have anti-hyperalgesic effect, improve the cognitive impairment caused and have an anxiolytic-like effect. Furthermore, the β-cyclodextrin/myrtenol complex decrease lipoperoxidation, increased catalase activity and a reduce SOD/CAT ratio. Therefore, β-cyclodextrin/myrtenol complex reduce painful behavior, improves motor skills and emotional behavior and decreases oxidative stress in a fibromyalgia model. | pt_BR |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | pt_BR |
| Affilliation | Federal University of São Paulo. Department of Biosciences. Santos, SP, Brazil. | pt_BR |
| Affilliation | Federal University of São Paulo. Department of Biosciences. Santos, SP, Brazil. | pt_BR |
| Affilliation | Federal University of São Paulo. Department of Biosciences. Santos, SP, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Engenharia de Tecidos e Imunofarmacologia. Salvador, BA, Brasil . | pt_BR |
| Affilliation | Federal University of Goias. School of Pharmacy. Goiania, GO, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil. | pt_BR |
| Affilliation | Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil. | pt_BR |
| Affilliation | Federal University of Paraíba. Cheminformatics Laboratory. Postgraduate Program in Natural Products and Synthetic Bioactive. João Pessoa, PB, Brazil. | pt_BR |
| Affilliation | . Federal University of Paraíba. Cheminformatics Laboratory. Postgraduate Program in Natural Products and Synthetic Bioactive. João Pessoa, PB, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil. | pt_BR |
| Subject | Chronic pain | pt_BR |
| Subject | Fibromyalgia | pt_BR |
| Subject | Inclusion complex | pt_BR |
| Subject | Myrtenol | pt_BR |
| Subject | Cyclodextrin | pt_BR |
| Subject | Oxidative stress | pt_BR |
