| Author | Mazeraud, Aurélien | |
| Author | Righy, Cássia | |
| Author | Bouchereau, Eleonore | |
| Author | Benghanem, Sarah | |
| Author | Bozza, Fernando A. | |
| Author | Sharshar, Tarek | |
| Access date | 2020-07-23T20:46:33Z | |
| Available date | 2020-07-23T20:46:33Z | |
| Document date | 2020 | |
| Citation | MAZERAUD, Aurélien et al. “Septic-Associated Encephalopathy: a Comprehensive Review. Neurotherapeutics, v. 17, n. 2, p. 392-403, 2020. | pt_BR |
| ISSN | 1933-7213 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/42365 | |
| Language | eng | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Septic-Associated Encephalopathy: a Comprehensive Review | pt_BR |
| Type | Article | |
| DOI | 10.1007/s13311-020-00862-1 | |
| Abstract | Septic-associated encephalopathy (SAE) is a key manifestation of sepsis, ranging from delirium to coma and occurring in up to 70% of patients admitted to the ICU. SAE is associated with higher ICU and hospital mortality, and also with poorer long-term outcomes, including cognitive and functional outcomes. The pathophysiology of SAE is complex, and it may involve neurotransmitter dysfunction, inflammatory and ischemic lesions to the brain, microglial activation, and blood-brain barrier dysfunction. Delirium (which is included in the SAE spectrum) is mostly diagnosed with validated scales in the ICU population. There is no established treatment for SAE; benzodiazepines should generally be avoided in this setting. Nonpharmacological prevention and management is key for treating SAE; it includes avoiding oversedation (mainly with benzodiazepines), early mobilization, and sleep promotion. | pt_BR |
| Affilliation | GHU Paris Psychiatrie et Neuroscience. Neurointensive Care and Neuroanesthesia Department. Paris, France / Hôpital Européen Georges Pompidou. Medical Intensive Care Unit. Paris, France / Université de Paris. Paris, France. | pt_BR |
| Affilliation | GHU Paris Psychiatrie et Neuroscience. Neurointensive Care and Neuroanesthesia Department. Paris, France / Instituto Estadual do Cérebro Paul Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | GHU Paris Psychiatrie et Neuroscience. Neurointensive Care and Neuroanesthesia Department. Paris, France / Hôpital Européen Georges Pompidou. Medical Intensive Care Unit. Paris, France / Université de Paris. Paris, France. | pt_BR |
| Affilliation | Université de Paris. Paris, France / Centre Hospitalier Universitaire Cochin. Médecine Intensive et Réanimation. Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | GHU Paris Psychiatrie et Neuroscience. Neurointensive Care and Neuroanesthesia Department. Paris, France / Université de Paris. Paris, France. | pt_BR |
| Subject | Sepsis | pt_BR |
| Subject | Blood–brain barrier | pt_BR |
| Subject | Microglia | pt_BR |
| Subject | Neuroanatomy | pt_BR |
| Subject | Neuroinflammation | pt_BR |
| Subject | Sepsis-associated encephalopathy | pt_BR |
| Embargo date | 2051-01-01 | |
