| Author | Silva, Janaína M. | |
| Author | Wippel, Helisa Helena | |
| Author | Verissimo, Denildo C. A. | |
| Author | Santos, Renata M. | |
| Author | Nogueira, Fábio C. S. | |
| Author | Passos, Gustavo A. R. | |
| Author | Sprengel, Sergio L. | |
| Author | Borba, Luis A. B. | |
| Author | Carvalho, Paulo Costa | |
| Author | Fischer, Juliana de Saldanha da Gama | |
| Access date | 2020-08-03T22:11:30Z | |
| Available date | 2020-08-03T22:11:30Z | |
| Document date | 2020 | |
| Citation | SILVA, Janaina M. et al. Proteomics pinpoints alterations in grade I meningiomas of male versus female patients. Plos One, v. 10, n. 10335, p. 1-11, 2020. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/42522 | |
| Language | por | pt_BR |
| Publisher | Nature Research | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Meningioma | pt_BR |
| Title | Proteomics pinpoints alterations in grade I meningiomas of male versus female patients | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1038/s41598-020-67113-3 | |
| Abstract | Meningiomas are among the most common primary tumors of the central nervous system (CNS) and originate from the arachnoid or meningothelial cells of the meninges. Surgery is the first option of treatment, but depending on the location and invasion patterns, complete removal of the tumor is not always feasible. Reports indicate many differences in meningiomas from male versus female patients; for example, incidence is higher in females, whereas males usually develop the malignant and more aggressive type. With this as motivation, we used shotgun proteomics to compare the proteomic profile of grade I meningioma biopsies of male and female patients. Our results listed several differentially abundant proteins between the two groups; some examples are S100-A4 and proteins involved in RNA splicing events. For males, we identified enriched pathways for cell-matrix organization and for females, pathways related to RNA transporting and processing. We believe our findings contribute to the understanding of the molecular differences between grade I meningiomas of female and male patients. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil / Universidade Federal do Paraná. Hospital de Clínicas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Química. Unidade Proteômica. Laboratório de Química de Proteínas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Química. Unidade Proteômica. Laboratório de Química de Proteínas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Universitário Evangélico Mackenzie. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Hospital de Clínicas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Hospital de Clínicas. Curitiba, PR, Brasil / Hospital Universitário Evangélico Mackenzie. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil. | pt_BR |
| Subject | Molecular Structure | pt_BR |
| Subject | Male | pt_BR |
| Subject | Female | pt_BR |
| Subject | Central Nervous System Neoplasms | pt_BR |
| Subject in Spanish | Estructura Molecular | pt_BR |
| Subject in Spanish | Femenino | pt_BR |
| Subject in Spanish | Neoplasias del Sistema Nervioso Central | pt_BR |
| DeCS | Estrutura Molecular | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Neoplasias do Sistema Nervoso Central | pt_BR |
| e-ISSN | 2045-2322 | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
