| Author | Bonfim, Tatiane Cristina dos Santos | |
| Author | Martins, Florence Gonçalves | |
| Author | Tunholi-Alves, Vinícius Menezes | |
| Author | Lima, Mariana Gomes | |
| Author | Mota, Ester Maria | |
| Author | Maldonado, Arnaldo | |
| Author | Pinheiro, Jairo | |
| Author | Garcia, Juberlan | |
| Access date | 2020-08-05T19:00:50Z | |
| Available date | 2020-08-05T19:00:50Z | |
| Document date | 2020 | |
| Citation | BONFIM, Tatiane Cristina dos Santos et al. Evaluation of changes in the carbohydrate metabolism of Biomphalaria glabrata Say, 1818 exposed to experimental coinfection by Angiostrongylus cantonensis (Nematoda) and Echinostoma paraensei (Trematoda). Journal of Invertebrate Pathology, v. 170, 107314, 6p, 2020. | pt_BR |
| ISSN | 0022-2011 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/42555 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Metabolismo anaeróbico | pt_BR |
| Subject in Portuguese | Co-infecção | pt_BR |
| Subject in Portuguese | Relação parasita-hospedeiro | pt_BR |
| Subject in Portuguese | Alterações metabólicas | pt_BR |
| Title | Evaluation of changes in the carbohydrate metabolism of Biomphalaria glabrata Say, 1818 exposed to experimental coinfection by Angiostrongylus cantonensis (Nematoda) and Echinostoma paraensei (Trematoda) | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jip.2019.107314 | |
| Abstract | The interaction between intermediate snail hosts and helminths can cause metabolic changes in the former. The snails use their reserves for maintenance of their vital processes, by activating the internal defense system and repairing tissue damage, while also supplying necessary energy for the parasites' development. Our aims were to evaluate the lactate dehydrogenase activity and the glucose concentration in the hemolymph of Biomphalaria glabrata experimentally coinfected by Angiostrongylus cantonensis and Echinostoma paraensei. Besides these aspects, the glycogen content in the digestive gland complex and cephalopedal mass along with histochemical changes in parasitized snails were analyzed. The snails were divided in group A (infected by 1200 L1 of A. cantonensis), group E (infected by 20 E. paraensei miracidia), group A + E (co-infected with A. cantonensis first and after a week by E. paraensei), group E + A (co-infected with E. paraensei first and then by A. cantonensis) and control group (not infected). During four weeks after exposure, samples were collected for biochemical and histochemical analyses. In the infected snails, glucose levels and glycogen content in the digestive gland complex and cephalopedal mass were significantly lower, in contrast with an increase of lactate dehydrogenase activity. These results indicate that the intense energy demand resulting from the presence of parasites causes the host snail to accelerate the anaerobic degradation of carbohydrates to obtain energy, in an attempt to maintain homeostasis. Both parasites were observed in histochemical analysis to cause tissue damages in the snails. So, although the snails were able to sustain the coinfection, several metabolic and tissue changes occurred, mainly in those infected with E. paraensei and then with A. cantonensis. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Curso de Pós-Graduação em Ciências Veterinárias. Seropédica, RJ, Brasil / Universidade Federal Rural do Rio de Janeiro. Instituto de Biologia. Departamento de Ciências Fisiológicas. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Biologia. Departamento de Ciências Fisiológicas. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Curso de Pós-Graduação em Ciências Veterinárias. Seropédica, RJ, Brasil / Universidade Federal Rural do Rio de Janeiro. Instituto de Biologia. Departamento de Ciências Fisiológicas. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência Nacional em Esquistossomose – Malacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Biologia. Departamento de Ciências Fisiológicas. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Anaerobic metabolism | pt_BR |
| Subject | Coinfection | pt_BR |
| Subject | Host-parasite relationship | pt_BR |
| Subject | Metabolic changes | pt_BR |
| Embargo date | 2022-01-01 | |
