| Author | Patrial, Yasmin Coelho | |
| Author | Tortorelli, Luma Petri | |
| Author | Rodrigues, Ana Claudia Souza | |
| Author | Santos, Ivson Cassiano de Oliveira | |
| Author | Chaves, Cláudia Elizabeth Volpe | |
| Author | Capato, Gislaine Souza | |
| Author | Barbosa, Gustavo Augusto Ribeiro | |
| Author | Carvalho-Assef, Ana Paula D' A. | |
| Author | Chang, Marilene Rodrigues | |
| Access date | 2020-08-06T18:27:47Z | |
| Available date | 2020-08-06T18:27:47Z | |
| Document date | 2019 | |
| Citation | PATRIAL, Yasmin Coelho et al. Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases. Rev. Inst. Med. Trop. São Paulo, v. 61, e 69, 5p, 2019. | pt_BR |
| ISSN | 1678-9946 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/42577 | |
| Language | eng | pt_BR |
| Publisher | Instituto de Medicina Tropical de São Paulo | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Meningite | pt_BR |
| Subject in Portuguese | Klebsiella pneumoniae | pt_BR |
| Subject in Portuguese | Resistente ao carbapenem | pt_BR |
| Subject in Portuguese | Beta-lactamases | pt_BR |
| Subject in Portuguese | Fluido cefalorraquidiano | pt_BR |
| Title | Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases | pt_BR |
| Type | Article | |
| DOI | 10.1590/S1678-9946201961069 | |
| Abstract | Nosocomial bacterial infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) is associated with high mortality in neurosurgical patients. There are few reports in the literature on meningitis caused by CRKP. We report two cases of CRKP meningitis after neurosurgery. The K. pneumoniae identification and antimicrobial susceptibility testing were performed using the Vitek Compact System. Minimum inhibitory concentrations of polymyxin B were determined using the broth microdilution method. Molecular typing of K. pneumoniae isolates was investigated using multilocus sequence typing. Antimicrobial susceptibility testing showed that the K. pneumoniae isolates were multidrug resistant and co-produced extended-spectrum β-lactamases and KPC enzymes. The patients were treated with intrathecal polymyxin. Genetic polymorphism analyses revealed two different K. pneumoniae clones (ST1298 and ST2687), which were observed for the first time in CRKP infections. We recommend intravenous administration of intrathecal polymyxin for treating meningitis caused by multidrug-resistant K. pneumoniae . | pt_BR |
| Affilliation | Universidade Anhanguera Uniderp. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Universidade Anhanguera Uniderp. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Universidade Anhanguera Uniderp. Campo Grande, MS, Brasil / Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Saúde e Desenvolvimento na Região Centro Oeste. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Regional de Mato Grosso do Sul. Campo Grande, MS, Brasil / Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Hospital Santa Casa. Campo Grande. MS, Brasil. | pt_BR |
| Affilliation | Hospital Santa Casa. Campo Grande. MS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso do Sul. Laboratório de Pesquisas Microbiológicas. Campo Grande, MS, Brasil. | pt_BR |
| Subject | Meningitis | pt_BR |
| Subject | Klebsiella pneumoniae | pt_BR |
| Subject | Carbapenem-resistant | pt_BR |
| Subject | Beta-lactamases | pt_BR |
| Subject | Cerebrospinal fluid | pt_BR |
