| Author | Chagas, Luana da Silva | |
| Author | Sandre, Poliana Capucho | |
| Author | Ribeiro, Natalia Cristina Aparecida Ribeiro e | |
| Author | Marcondes, Henrique | |
| Author | Silva, Priscilla Oliveira | |
| Author | Savino, Wilson | |
| Author | Serfaty, Claudio A. | |
| Access date | 2020-08-07T20:03:11Z | |
| Available date | 2020-08-07T20:03:11Z | |
| Document date | 2020 | |
| Citation | CHAGAS, Luana da Silva et al. Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease. International Journal of Molecular Sciences, v. 21, n. 2111, p. 1-20, 2020. | pt_BR |
| ISSN | 1661-6596 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/42597 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Neuroinflamação | pt_BR |
| Subject in Portuguese | Desenvolvimento cerebral | pt_BR |
| Subject in Portuguese | Cross-talk de células imunes | pt_BR |
| Subject in Portuguese | Neuroplasticidade | pt_BR |
| Subject in Portuguese | Fatores ambientais | pt_BR |
| Subject in Portuguese | Ativação microglial | pt_BR |
| Title | Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease | pt_BR |
| Type | Article | |
| DOI | 10.3390/ijms21062111 | |
| Abstract | Recent discoveries on the neurobiology of the immunocompetent cells of the central nervous system (CNS), microglia, have been recognized as a growing field of investigation on the interactions between the brain and the immune system. Several environmental contexts such as stress, lesions, infectious diseases, and nutritional and hormonal disorders can interfere with CNS homeostasis, directly impacting microglial physiology. Despite many encouraging discoveries in this field, there are still some controversies that raise issues to be discussed, especially regarding the relationship between the microglial phenotype assumed in distinct contexts and respective consequences in different neurobiological processes, such as disorders of brain development and neuroplasticity. Also, there is an increasing interest in discussing microglial-immune system cross-talk in health and in pathological conditions. In this review, we discuss recent literature concerning microglial function during development and homeostasis. In addition, we explore the contribution of microglia to synaptic disorders mediated by different neuroinflammatory outcomes during pre- and postnatal development, with long-term consequences impacting on the risk and vulnerability to the emergence of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o TImo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimmunomodulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o TImo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimmunomodulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimmunomodulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Neuroinflammation | pt_BR |
| Subject | Brain development; | pt_BR |
| Subject | Immune cell cross-talk | pt_BR |
| Subject | Neuroplasticity | pt_BR |
| Subject | Environmental factors | pt_BR |
| Subject | Microglial activation | pt_BR |
| e-ISSN | 1422-0067 | |
