| Author | Monteiro, Eliana Ferreira | |
| Author | Fernandez-Becerra, Carmen | |
| Author | Araujo, Maisa da Silva | |
| Author | Messias, Mariluce Rezende | |
| Author | Ozaki, Luiz Shozo | |
| Author | Duarte, Ana Maria Ribeiro de Castro | |
| Author | Bueno, Marina Galvão | |
| Author | Dias, Jose Luiz Catao | |
| Author | Chagas, Carolina Romeiro Fernandes | |
| Author | Mathias, Bruno da Silva | |
| Author | Santos, Mayra Gomes dos | |
| Author | Santos, Stéfanie Vanessa | |
| Author | Holcman, Marcia Moreira | |
| Author | Jr, Julio Cesar de Souza | |
| Author | Kirchgatter, Karin | |
| Access date | 2020-08-10T17:57:13Z | |
| Available date | 2020-08-10T17:57:13Z | |
| Document date | 2020 | |
| Citation | MONTEIRO, Eliana Ferreira et al. Naturally Acquired Humoral Immunity against Malaria Parasites in Non-Human Primates from the Brazilian Amazon, Cerrado and Atlantic Forest. Pathogens, v. 9, n. 525, p. 1-11, 2020. | pt_BR |
| ISSN | 2076-0817 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/42617 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Malária | pt_BR |
| Subject in Portuguese | Plasmodium malária | pt_BR |
| Subject in Portuguese | Sorologia | pt_BR |
| Subject in Portuguese | Primatas não humanos | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Naturally Acquired Humoral Immunity against Malaria Parasites in Non-Human Primates from the Brazilian Amazon, Cerrado and Atlantic Forest | pt_BR |
| Type | Article | |
| DOI | 10.3390/pathogens9070525 | |
| Abstract | Non-human primates (NHPs) have been shown to be infected by parasites of the genus Plasmodium, the etiological agent of malaria in humans, creating potential risks of zoonotic transmission. Plasmodium brasilianum, a parasite species similar to P. malariae of humans, have been described in NHPs from Central and South America, including Brazil. The merozoite surface protein 1 (MSP1), besides being a malaria vaccine candidate, is highly immunogenic. Due to such properties, we tested this protein for the diagnosis of parasite infection. We used recombinant proteins of P. malariae MSP1, as well as of P. falciparum and P. vivax, for the detection of antibodies anti-MSP1 of these parasite species, in the sera of NHPs collected in different regions of Brazil. About 40% of the NHP sera were confirmed as reactive to the proteins of one or more parasite species. A relatively higher number of reactive sera was found in animals from the Atlantic Forest than those from the Amazon region, possibly reflecting the former more intense parasite circulation among NHPs due to their proximity to humans at a higher populational density. The presence of Plasmodium positive NHPs in the surveyed areas, being therefore potential parasite reservoirs, needs to be considered in any malaria surveillance program. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universitat de Barcelona. ISGlobal, Hospital Clínic. Barcelona, Spain / Germans Trias i Pujol Health Science Research Institute. Badalona, Spain. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz Rondônia. Instituto Oswaldo Cruz. Rondônia, RO, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Rondônia. Departamento de Biologia. Porto Velho, RO, Brasil. | pt_BR |
| Affilliation | Virginia Commonwealth University. Life Sciences. Richmond, VA, USA. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brasil / Superintendência de Controle de Endemias. Departamento de Laboratórios Especializados. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Patologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Parque Zoológico de São Paulo. Departamento de Pesquisas Aplicadas. São Paulo, SP, Brasil / Institute of Ecology, Nature Research Centre, Vilnius, Lithuania. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Cruzeiro do Sul. Departamento de Patologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Cruzeiro do Sul. Departamento de Patologia. São Paulo, SP, Brasil / AC Camargo Cancer Center. Departamento de Anatomia Patológica. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Superintendência de Controle de Endemias. Departamento de Laboratórios Especializados. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Universidade Regional de Blumenau. Departamento de Medicina Veterinária. Blumenau, SC, Brasil / Centro de Pesquisas Biológicas. Projeto Bugio, Indaial, SC, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brasil / Superintendência de Controle de Endemias. Departamento de Laboratórios Especializados. São Paulo, SP, Brasil. | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Plasmodium malariae | pt_BR |
| Subject | MSP1 | pt_BR |
| Subject | Non-human primates | pt_BR |
| Subject | Serology | pt_BR |
| Subject | Brazil | pt_BR |
