Author | Prata-Barbosa, Arnaldo | |
Author | Lima-Setta, Fernanda | |
Author | Santos, Gustavo Rodrigues dos | |
Author | Lanziotti, Vanessa Soares | |
Author | Castro, Roberta Esteves Vieira de | |
Author | Souza, Daniela Carla de | |
Author | Raymundo, Carlos Eduardo | |
Author | Oliveira, Felipe Rezende Caino de | |
Author | Lima, Lucio Flavio Peixoto de | |
Author | Tonial, Cristian Tedesco | |
Author | Colleti, José | |
Author | Bellinat, Ana Paula Novaes | |
Author | Lorenzo, Vivian Botelho | |
Author | Zeitel, Raquel de Seixas | |
Author | Pulcheri, Lucas | |
Author | Costa, Fernanda Ciuffo Monte da | |
Author | La Torre, Fabíola Peixoto Ferreira | |
Author | Figueiredo, Elaine Augusta das Neves | |
Author | Silva, Thiago Peres da | |
Author | Riveiro, Paula Marins | |
Author | Mota, Isabele Coelho Fonseca da | |
Author | Brandão, Igor Bromonschenkel | |
Author | Azevedo, Zina Maria Almeida de | |
Author | Gregory, Simone Camera | |
Author | Boedo, Fernanda Raquel Oliveira | |
Author | Carvalho, Rosana Novais de | |
Author | Castro, Natália Almeida de Arnaldo Silva Rodriguez | |
Author | Genu, Daniel Hilário Santos | |
Author | Foronda, Flavia Andrea Krepel | |
Author | Cunha, Antonio José Ledo A. | |
Author | Magalhães-Barbosa, Maria Clara de | |
Access date | 2020-08-12T20:13:10Z | |
Available date | 2020-08-12T20:13:10Z | |
Document date | 2020 | |
Citation | PRATA-BARBOSA, Arnaldo et al. Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study. Jornal de Pediatria, p. 1-11, 2020. | pt_BR |
ISSN | 0021-7557 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/42737 | |
Language | eng | pt_BR |
Publisher | Sociedade Brasileira de Pediatria (SBP) | pt_BR |
Publisher | Elsevier | pt_BR |
Later version | https://www.arca.fiocruz.br/handle/icict/44322 | pt_BR |
Rights | open access | pt_BR |
Title | Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study | pt_BR |
Type | Preprint | pt_BR |
DOI | 10.1016/j.jped.2020.07.002 | |
Abstract | Objective: To describe the clinical characteristics of children and adolescents admitted to intensive care with confirmed COVID-19. Method: Prospective, multicenter, observational study, in 19 pediatric intensive care units. Patients aged 1 month to 19 years admitted consecutively (March–May 2020) were included. Demographic, clinical-epidemiological features, treatment, and outcomes were collected. Subgroups were compared according to comorbidities, age < 1 year, and need for invasive mechanical ventilation. A multivariable logistic regression model was used for predictors of severity. Results: Seventy-nine patients were included (ten with multisystemic inflammatory syndrome). Median age 4 years; 54% male (multisystemic inflammatory syndrome, 80%); 41% had comorbidities (multisystemic inflammatory syndrome, 20%). Fever (76%), cough (51%), and tachypnea (50%) were common in both groups. Severe symptoms, gastrointestinal symptoms, and higher inflammatory markers were more frequent in multisystemic inflammatory syndrome. Interstitial lung infiltrates were common in both groups, but pleural effusion was more prevalent in the multisystemic inflammatory syndrome group (43% vs. 14%). Invasive mechanical ventilation was used in 18% (median 7.5 days); antibiotics, oseltamivir, and corticosteroids were used in 76%, 43%, and 23%, respectively, but not hydroxychloroquine. The median pediatric intensive care unit length-of-stay was five days; there were two deaths (3%) in the non- multisystemic inflammatory syndrome group. Patients with comorbidities were older, and comorbidities were independently associated with the need for invasive mechanical ventilation (OR 5.5; 95% CI, 1.43–21.12; p = 0.01). Conclusions: In Brazilian pediatric intensive care units, COVID-19 had low mortality, age less than 1 year was not associated with a worse prognosis, and patients with multisystemic inflammatory syndrome had more severe symptoms, higher inflammatory biomarkers, and a greater predominance of males, but only comorbidities and chronic diseases were independent predictors of severity. | pt_BR |
Affilliation | Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Sírio Libanês. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Hospital Alvorada Moema, São Paulo, SP, Brasil. | pt_BR |
Affilliation | Hospital SEPACO. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Pontifícia Universidade Católica. Porto Alegre, RS, Brasil. | pt_BR |
Affilliation | Hospital Assunção. São Bernardo do Campo, SP, Brasil. | pt_BR |
Affilliation | Hospital Martagão Gesteira. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital Couto Maia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Hospital Pedro Ernesto. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Rios D’Or. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Quinta D’Or. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Sino Brasileiro. Osasco, SP, Brasil. | pt_BR |
Affilliation | Hospital Pediátrico Unimed. Belém, PA, Brasil. | pt_BR |
Affilliation | Hospital Real D’Or. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Caxias D’Or. Duque de Caxias, RJ, Brasil. | pt_BR |
Affilliation | Hospital Jutta Batista. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Hospital Niteroi D’Or. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Estadual da Criança. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Norte D’Or. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Santa Casa da Misericórdia. Hospital Santa Izabel. Salvador, BA, Brasil. | pt_BR |
Affilliation | Faculdade de Medicina. Hospital da Criança. São José do Rio Preto, SP, Brasil. | pt_BR |
Affilliation | Hospital Estadual Getúlio Vargas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Sirio-Libanes. Sao Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Brazilian Research Network in Pediatric Intensive Care. São Paulo, SP, Brasil. | pt_BR |
Subject | COVID-19 | pt_BR |
Subject | SARS-CoV-2 | pt_BR |
Subject | Pediatric intensive care | pt_BR |
Subject | Pediatrics | pt_BR |
Subject | Brazil | pt_BR |