Author | Arijit, Bhattacharya | |
Author | Corbeil, Audrey | |
Author | Monte Neto, Rubens Lima do | |
Author | Fernandez-Prada, Christopher | |
Access date | 2020-08-24T17:21:21Z | |
Available date | 2020-08-24T17:21:21Z | |
Document date | 2020 | |
Citation | BHATTACHARYA, Arijit et al. Of Drugs and Trypanosomatids: New Tools and Knowledge to Reduce Bottlenecks in Drug Discovery. Genes, v. 11, n. 7, 722, 2020 | pt_BR |
ISSN | 2073-4425 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/42925 | |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Title | Of Drugs and Trypanosomatids: New Tools and Knowledge to Reduce Bottlenecks in Drug Discovery | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/genes11070722 | |
Abstract | Leishmaniasis (Leishmania species), sleeping sickness (Trypanosoma brucei), and Chagas disease (Trypanosoma cruzi) are devastating and globally spread diseases caused by trypanosomatid parasites. At present, drugs for treating trypanosomatid diseases are far from ideal due to host toxicity, elevated cost, limited access, and increasing rates of drug resistance. Technological advances in parasitology, chemistry, and genomics have unlocked new possibilities for novel drug concepts and compound screening technologies that were previously inaccessible. In this perspective, we discuss current models used in drug-discovery cascades targeting trypanosomatids (from in vitro to in vivo approaches), their use and limitations in a biological context, as well as different examples of recently discovered lead compounds. | pt_BR |
Affilliation | Adamas University | pt_BR |
Affilliation | Université de Montréal | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Université de Montréal | pt_BR |
Subject | trypanosomatids | pt_BR |
Subject | neglected tropical diseases | pt_BR |
Subject | Leishmania | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Trypanosoma brucei | pt_BR |
Subject | drug discovery | pt_BR |
Subject | in vitro models | pt_BR |
Subject | in vivo models | pt_BR |
Subject | genomics | pt_BR |
Subject | drug resistance | pt_BR |