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| Autor | Vargas, Gabriele | |
| Autor | Geraldo, Luiz Henrique Medeiros | |
| Autor | Salomão, Natália Gedeão | |
| Autor | Paes, Marciano Viana | |
| Autor | Lima, Flavia Regina Souza | |
| Autor | Gomes, Flávia Carvalho Alcantara | |
| Fecha de acceso | 2020-08-31T21:36:40Z | |
| Fecha de disponibilización | 2020-08-31T21:36:40Z | |
| Fecha de publicación | 2020 | |
| Referencia | VARGAS, Gabriele et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives. Brain, Behavior, & Immunity - Health, v. 7, 100127, p. 1-13, 2020. | pt_BR |
| ISSN | 2666-3546 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43095 | |
| Descripción | Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. | pt_BR |
| Idioma | eng | pt_BR |
| Editor | Elsevier | pt_BR |
| Derechos de autor | open access | |
| Palabras clave en Portugués | SARS-CoV-2 | pt_BR |
| Palabras clave en Portugués | COVID-19 | pt_BR |
| Palabras clave en Portugués | Coronavírus | pt_BR |
| Palabras clave en Portugués | Neuroinflamação | pt_BR |
| Palabras clave en Portugués | Neuroglia | pt_BR |
| Palabras clave en Portugués | Astrócitos | pt_BR |
| Palabras clave en Portugués | Microglia | pt_BR |
| Título | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives | pt_BR |
| Tipo del documento | Article | |
| DOI | 10.1016/j.bbih.2020.100127 | pt_BR |
| Resumen en Inglés | In December 2019, a pneumonia outbreak was reported in Wuhan, Hubei province, China. Since then, the World Health Organization declared a public health emergency of international concern due to a growing number of deaths around the globe, as well as unparalleled economic and sociodemographic consequences. The disease called coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), a novel form of human coronavirus. Although coronavirus infections have been associated with neurological manifestations such as febrile seizures, convulsions, change in mental status, and encephalitis, less is known about the impact of SARS-CoV-2 in the brain. Recently, emerging evidence suggests that SARS-CoV-2 is associated with neurological alterations in COVID-19 patients with severe clinical manifestations. The molecular and cellular mechanisms involved in this process, as well as the neurotropic and neuroinvasive properties of SARS-CoV-2, are still poorly understood. Glial cells, such as astrocytes and microglia, play pivotal roles in the brain response to neuroinflammatory insults and neurodegenerative diseases. Further, accumulating evidence has shown that those cells are targets of several neurotropic viruses that severely impact their function. Glial cell dysfunctions have been associated with several neuroinflammatory diseases, suggesting that SARS-CoV-2 likely has a primary effect on these cells in addition to a secondary effect from neuronal damage. Here, we provide an overview of these data and discuss the possible implications of glial cells as targets of SARS-CoV-2. Considering the roles of microglia and astrocytes in brain inflammatory responses, we shed light on glial cells as possible drivers and potential targets of therapeutic strategies against neurological manifestations in patients with COVID19. The main goal of this review is to highlight the need to consider glial involvement in the progression of COVID-19 and potentially include astrocytes and microglia as mediators of SARS-CoV-2-induced neurological damage. | pt_BR |
| Afiliación | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Université de Paris. Paris Cardiovascular Research Center (PARCC - INSERM U970). Paris, France. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Palavras clave en Inglês | Glial cells | pt_BR |
| Palavras clave en Inglês | Astrocyte | pt_BR |
| Palavras clave en Inglês | Microglia | pt_BR |
| Palavras clave en Inglês | SARS-CoV-2 | pt_BR |
| Palavras clave en Inglês | COVID-19 | pt_BR |
| Palavras clave en Inglês | Coronavirus | pt_BR |
| Palavras clave en Inglês | Neuroinflammation | pt_BR |
| DeCS | Neuroglia | pt_BR |
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