| Author | Zampieri, Fernando G. | |
| Author | Granholm, Anders | |
| Author | Møller, Morten Hylander | |
| Author | Scotti, Alexandre Vaz | |
| Author | Alves, Alessandra | |
| Author | Cabral, Maurício Magalhães | |
| Author | Sousa, Marcelo Ferreira | |
| Author | Balieiro, Henrique Miller | |
| Author | Hortala, Carlos Cesar | |
| Author | Filho, Edison Moraes Rodrigues | |
| Author | Perecmanis, Eric | |
| Author | Magalhães Menezes, Márcia Adélia | |
| Author | Moreira, Carlos Eduardo Nassif | |
| Author | Moralez, Giulliana Martines | |
| Author | Bafi, Antônio Tonete | |
| Author | Carvalho, Clayton Barbieri | |
| Author | Salluh, Jorge Ibrain Figueira | |
| Author | Bozza, Fernando A. | |
| Author | Perner, Anders | |
| Author | Soares, Marcio | |
| Access date | 2020-09-01T21:58:34Z | |
| Available date | 2020-09-01T21:58:34Z | |
| Document date | 2020 | |
| Citation | ZAMPIERI, Fernando G. et al. Customization and external validation of the Simplified Mortality Score for the Intensive Care Unit (SMS-ICU) in Brazilian critically ill patients. Journal of Critical Care, v. 59, p. 94-100, 2020. | pt_BR |
| ISSN | 0883-9441 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43147 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Critical care | pt_BR |
| Subject in Portuguese | Illness severity scores | pt_BR |
| Subject in Portuguese | Outcome | pt_BR |
| Title | Customization and external validation of the Simplified Mortality Score for the Intensive Care Unit (SMS-ICU) in Brazilian critically ill patients | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jcrc.2020.05.016 | pt_BR |
| Abstract | Purpose: To customize and externally validate the recently proposed Simplified Mortality Score for the ICU (SMS-ICU, a simple score for 90-day mortality that has no need for ancillary testing results) for in-hospital mortality and to compare its performance to SAPS 3.
Material and methods: We used data from two distinct large cohorts of adult Brazilian patients with unplanned ICU admissions to perform a first-level customization (43,017 patients admitted to 78 ICUs) of the original SMS-ICU score for in-hospital mortality and, sequentially, externally validate it (313,365 patients admitted to 99 ICUs). Performance of SMS-ICU was assessed through measurements of discrimination and calibration and compared with SAPS 3.
Results: In the validation cohort, median SMS-ICU was 13 (IQR 8-16) points and median SAPS 3 was 44 (IQR 36-51). Discrimination of SMS-ICU was good (AUC 0.817; 95% CI 0.814-0.819) but slightly lower than of SAPS 3 (AUC 0.845; 95% CI 0.843-0.848;). The customized SMS-ICU predictions were comparable to SAPS 3 in terms of calibration.
Conclusion: In this external validation of the SMS-ICU in a large Brazilian cohort, we observed good discrimination of SMS-ICU and acceptable calibration after first-level customization. SMS-ICU can be used as a measure of illness severity for acutely admitted ICU patients in clinical studies. | pt_BR |
| Affilliation | D'Or Institute for Research and Education. Department of Critical Care. São Paulo, SP, Brazil / HCor-Hospital do Coração. Research Institute. São Paulo, SP, Brazil / University of Southern Denmark. Center for Epidemiological Research. Odense, Denmark. | pt_BR |
| Affilliation | Copenhagen University Hospital. Department of Intensive Care 4131. Rigshospitalet, Copenhagen, Denmark. | pt_BR |
| Affilliation | Copenhagen University Hospital. Department of Intensive Care 4131. Rigshospitalet, Copenhagen, Denmark / Centre for Research in Intensive Care. Copenhagen, Denmark. | pt_BR |
| Affilliation | Hospital Badim. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Rios D'Or. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital São Marcos. Recife, PE, Brasil. | pt_BR |
| Affilliation | Santa Casa de Caridade de Diamantina. Diamantina, MG, Brasil. | pt_BR |
| Affilliation | SAMER Hospital. Resende, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Niteroi D'Or. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Santa Casa de Porto Alegre - Hospital Dom Vicente Scherer. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Hospital Caxias D'Or. Duque de Caxias, Brasil. | pt_BR |
| Affilliation | Hospital Oeste D'Or. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital 9 de Julho. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Hospital Estadual Getúlio Vargas. Rio de Janeiro, RJ, Brasil / D'Or Institute for Research and Education. Department of Critical Care. Graduate Program in Translational Medicine. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital SEPACO. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Hospital Brasília. Brasília, DF, Brasil. | pt_BR |
| Affilliation | D'Or Institute for Research and Education. Department of Critical Care. Graduate Program in Translational Medicine. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / D'Or Institute for Research and Education. Department of Critical Care. Graduate Program in Translational Medicine. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Copenhagen University Hospital. Department of Intensive Care 4131. Rigshospitalet, Copenhagen, Denmark. | pt_BR |
| Affilliation | D'Or Institute for Research and Education. Department of Critical Care. Graduate Program in Translational Medicine. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Embargo date | 2030-01-01 | |
| Event date | 2020 | |
