| Author | Daltro, Sérgio Ricardo Teixeira | |
| Author | Meira, Cássio Santana | |
| Author | Santos, Ivanilson Pimenta | |
| Author | Santos, Ricardo Ribeiro dos | |
| Author | Soares, Milena Botelho Pereira | |
| Access date | 2020-09-18T12:05:13Z | |
| Available date | 2020-09-18T12:05:13Z | |
| Document date | 2020 | |
| Citation | DALTRO, Sérgio Ricardo Teixeira et al. Mesenchymal Stem Cells and Atopic Dermatitis: A Review. Frontiers in Cell and Developmental Biology, v. 8, Article 326, p. 1-10, May 2020. | pt_BR |
| ISSN | 2296-634X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43444 | |
| Sponsorship | Brazilian Research Council (CNPq)/MS Grant
No. 443909/2018-0. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Células-tronco mesenquimais / estromais, | pt_BR |
| Subject in Portuguese | Dermatite atópica | pt_BR |
| Subject in Portuguese | Eczema atópico | pt_BR |
| Subject in Portuguese | Imunomodulação | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Doenças de pele | pt_BR |
| Title | Mesenchymal Stem Cells and Atopic Dermatitis: A Review | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3389/fcell.2020.00326 | pt_BR |
| Abstract | Mesenchymal stem/stromal cells (MSCs) are stromal-derived non-hematopoietic progenitor cells that reside in and can be expanded from various tissues sources of adult and neonatal origin, such as the bone marrow, umbilical cord, umbilical cord blood, adipose tissue, amniotic fluid, placenta, dental pulp and skin. The discovery of the immunosuppressing action of MSCs on T cells has opened new perspectives for their use as a therapeutic agent for immune-mediated disorders, including allergies. Atopic dermatitis (AD), a chronic and relapsing skin disorder that affects up to 20% of children and up to 3% of adults worldwide, is characterized by pruritic eczematous lesions, impaired cutaneous barrier function, Th2 type immune hyperactivation and, frequently, elevation of serum immunoglobulin E levels. Although, in the dermatology field, the application of MSCs as a therapeutic agent was initiated using the concept of cell replacement for skin defects and wound healing, accumulating evidence have shown that MSC-mediated immunomodulation can be applicable to the treatment of inflammatory/allergic skin disorders. Here we reviewed the pre-clinical and clinical studies and possible biological mechanisms of MSCs as a therapeutic tool for the treatment of atopic dermatitis. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil / Health Institute of Technology. National Industrial Learning Service. Integrated Manufacturing and Technology Campus (SENAI-CIMATEC). Salvador, BA, Brazil / National Institute of Science and Technology for Regenerative Medicine (INCT-REGENERA). Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil / Health Institute of Technology. National Industrial Learning Service. Integrated Manufacturing and Technology Campus (SENAI-CIMATEC). Salvador, BA, Brazil / National Institute of Science and Technology for Regenerative Medicine (INCT-REGENERA). Rio de Janeiro, RJ, Brazil. | pt_BR |
| Subject | Mesenchymal stem/stromal cells | pt_BR |
| Subject | Atopic dermatitis | pt_BR |
| Subject | Atopic eczema | pt_BR |
| Subject | Immunomodulation | pt_BR |
| Subject | Inflammatory skin diseases | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
