| Author | Castro, Solange L. de | |
| Author | Soeiro, Maria Nazaré C. | |
| Author | Meirelles, Maria de Nazareth Leal de | |
| Access date | 2020-09-19T17:43:39Z | |
| Available date | 2020-09-19T17:43:39Z | |
| Document date | 1992 | |
| Citation | CASTRO, Solange L. de; SOEIRO, Maria Nazaré C.; MEIRELLES, Maria de Nazareth Leal de. Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, n. 2, p. 209-215, Apr./June 1992. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43479 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Fenotiazinas | pt_BR |
| Subject in Portuguese | Parasitas | pt_BR |
| Subject in Portuguese | Interação da célula hospedeira | pt_BR |
| Title | Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02761992000200007 | |
| Abstract | Phenothiazines were observed to have a direct effect on Trypanosoma cruzi and on its in vitro interaction with host cells. They caused lysis of trypomastigotes (50 uM/24 h) and,to a lesser extent, epimastigote proliferation. Treatment of infected peritoneal macrophages with 12.5 uM chlorpromazine or triflupromazine inhibited the infection; this effect was found to be partially reversible if the drugs were removed after 24 h of treatment. At 60 uM, the drugs caused damage to amastigotes interiorized in heart muscle cells. However, the narrow margin of toxity between anti-trypanossomal activity and damage to host cells mitigates against in vivo investigation at the present time. Possible hypothesis for the mechanism of action of phenothiazines are discussed. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Phenothiazines | pt_BR |
| Subject | Parasite | pt_BR |
| Subject | Interaction | pt_BR |
| Subject | Host cells | pt_BR |
| e-ISSN | 1678-8060 | |
