| Author | Brasil, Patrícia | |
| Author | Vasconcelos, Zilton Farias Meira de | |
| Author | Kerin, Tara | |
| Author | Gabaglia, Claudia Raja | |
| Author | Ribeiro, Ieda P. | |
| Author | Bonaldo, Myrna C. | |
| Author | Damasceno, Luana | |
| Author | Pone, Marcos V. | |
| Author | Pone, Sheila Moura | |
| Author | Zin, Andrea | |
| Author | Tsui, Irena | |
| Author | Adachi, Kristina | |
| Author | Pereira Jr, Jose Paulo | |
| Author | Gaw, Stephanie L. | |
| Author | Carvalho, Liege | |
| Author | Cunha, Denise C. | |
| Author | Guida, Leticia | |
| Author | Rocha, Mirza | |
| Author | Cherry, James D. | |
| Author | Wang, Lulan | |
| Author | Aliyari, Saba | |
| Author | Cheng, Genhong | |
| Author | Foo, Suan-Sin | |
| Author | Chen, Weiqiang | |
| Author | Jung, Jae | |
| Author | Brickley, Elizabeth | |
| Author | Moreira, Maria Elisabeth L. | |
| Author | Nielsen-Saines, Karin | |
| Access date | 2020-09-22T19:35:07Z | |
| Available date | 2020-09-22T19:35:07Z | |
| Document date | 2020 | |
| Citation | BRASIL, Patrícia et al. Zika virus vertical transmission in children with confirmed antenatal exposure. Nature Communications, v. 11, n. 1, p. 1-8, 2020. | pt_BR |
| ISSN | 2041-1723 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43557 | |
| Language | eng | pt_BR |
| Publisher | Nature Research | pt_BR |
| Rights | open access | |
| Title | Zika virus vertical transmission in children with confirmed antenatal exposure | pt_BR |
| Type | Article | |
| DOI | 10.1038/s41467-020-17331-0 | |
| Abstract | We report Zika virus (ZIKV) vertical transmission in 130 infants born to PCR+ mothers at the time of the Rio de Janeiro epidemic of 2015-2016. Serum and urine collected from birth through the first year of life were tested by quantitative reverse transcriptase polymerase chain reaction (PCR) and/or IgM Zika MAC-ELISA. Four hundred and seven specimens are evaluated; 161 sera tested by PCR and IgM assays, 85 urines by PCR. Sixty-five percent of children (N = 84) are positive in at least one assay. Of 94 children tested within 3 months of age, 70% are positive. Positivity declines to 33% after 3 months. Five children are PCR+ beyond 200 days of life. Concordance between IgM and PCR results is 52%, sensitivity 65%, specificity 40% (positive PCR results as gold standard). IgM and serum PCR are 61% concordant; serum and urine PCR 55%. Most children (65%) are clinically normal. Equal numbers of children with abnormal findings (29 of 45, 64%) and normal findings (55 of 85, 65%) have positive results, p = 0.98. Earlier maternal trimester of infection is associated with positive results (p = 0.04) but not clinical disease (p = 0.98). ZIKV vertical transmission is frequent but laboratory confirmed infection is not necessarily associated with infant abnormalities. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | pt_BR |
| Affilliation | Biomedical Research Institute of Southern California. Oceanside, CA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of California. San Francisco School of Medicine. San Francisco, CA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | pt_BR |
| Affilliation | University of Southern California. Los Angeles, CA, USA. | pt_BR |
| Affilliation | University of Southern California. Los Angeles, CA, USA. | pt_BR |
| Affilliation | University of Southern California. Los Angeles, CA, USA. | pt_BR |
| Affilliation | London School of Hygiene and Tropical Medicine. Department of Infectious Disease Epidemiology. London, UK. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | Infectious diseases | pt_BR |
| Subject | Viral infection | pt_BR |
