| Autor | Barros Filho, Mateus C. | |
| Autor | Mello, Julia B. H. de | |
| Autor | Marchi, Fabio A. | |
| Autor | Pinto, Clóvis A. L. | |
| Autor | Silva, Igor C. da | |
| Autor | Damasceno, Patricia K. F. | |
| Autor | Soares, Milena Botelho Pereira | |
| Autor | Kowalski, Luiz P. | |
| Autor | Rogatto, Silvia R. | |
| Data de acesso | 2020-09-24T13:43:35Z | |
| Data de disponibilização | 2020-09-24T13:43:35Z | |
| Data do publicação | 2020 | |
| Citação | BARROS FILHO, Mateus C. et al. GADD45B Transcript Is a Prognostic Marker in Papillary Thyroid Carcinoma Patients Treated With Total Thyroidectomy and Radioiodine Therapy. Frontiers in Endocrinology, v. 11, p. 1-11, Apr. 2020. | pt_BR |
| ISSN | 1664-2392 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43598 | |
| Fomento | Fundação
de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
(2015/17707-5 and 2015/20748-5). | pt_BR |
| Idioma | eng | pt_BR |
| Editor | Frontiers Media | pt_BR |
| Direito Autoral | open access | pt_BR |
| Palavras-chave | Câncer papilar de tireoide | pt_BR |
| Palavras-chave | Prognóstico | pt_BR |
| Palavras-chave | Mutação | pt_BR |
| Palavras-chave | Perfil de transcrição | pt_BR |
| Título | GADD45B Transcript Is a Prognostic Marker in Papillary Thyroid Carcinoma Patients Treated With Total Thyroidectomy and Radioiodine Therapy | pt_BR |
| Tipo do documento | Article | pt_BR |
| DOI | 10.3389/fendo.2020.00269 | pt_BR |
| Resumo em Inglês | Currently, there is a lack of efficient recurrence prediction methods for papillary thyroid
carcinoma (PTC). In this study, we enrolled 202 PTC patients submitted to total
thyroidectomy and radioiodine therapy with long-term follow-up (median = 10.7 years).
The patients were classified as having favorable clinical outcome (PTC-FCO, no disease
in the follow-up) or recurrence (PTC-RE). Alterations in BRAF, RAS, RET, and TERT
were investigated (n = 202) and the transcriptome of 48 PTC (>10 years of follow-up)
samples was profiled. Although no mutation was associated with the recurrence risk,
68 genes were found as differentially expressed in PTC-RE compared to PTC-FCO.
Pathway analysis highlighted a potential role of cancer-related pathways, including
signal transduction and FoxO signaling. Among the eight selected genes evaluated
by RT-qPCR, SLC2A4 and GADD45B showed down-expression exclusively in the
PTC-FCO group compared to non-neoplastic tissues (NT). Increased expression of
GADD45B was an independent marker of shorter disease-free survival [hazard ratio
(HR) 2.9; 95% confidence interval (CI95) 1.2–7.0] in our cohort and with overall survival
in the TCGA dataset (HR = 4.38, CI95 1.2–15.5). In conclusion, GADD45B transcript
was identified as a novel prognostic marker candidate in PTC patients treated with total
thyroidectomy and radioiodine therapy. | pt_BR |
| Afiliação | International Research Center. A. C. Camargo Cancer Center. São Paulo, SP, Brazil. | pt_BR |
| Afiliação | International Research Center. A. C. Camargo Cancer Center. São Paulo, SP, Brazil. | pt_BR |
| Afiliação | International Research Center. A. C. Camargo Cancer Center. São Paulo, SP, Brazil. | pt_BR |
| Afiliação | A. C. Camargo Cancer Center. Department of Pathology, São Paulo, SP, Brazil. | pt_BR |
| Afiliação | São Rafael Hospital. Department of Pathology. Salvador, BA, Brazil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Afiliação | Fundaç ão Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Technology Institute. SENAI CIMATEC. Salvador, BA, Brazil. | pt_BR |
| Afiliação | A. C. Camargo Cancer Center. Department of Head and Neck Surgery and Otorhinolaryngology. São Paulo, SP, Brazil. | pt_BR |
| Afiliação | University of Southern Denmark. Institute of Regional Health Research. Department of Clinical Genetics. Vejle University Hospital.Odense. Denmark. | pt_BR |
| Palavras-chave em inglês | Papillary thyroid cancer | pt_BR |
| Palavras-chave em inglês | Prognostic markers | pt_BR |
| Palavras-chave em inglês | BRAF mutation | pt_BR |
| Palavras-chave em inglês | GADD45B | pt_BR |
| Palavras-chave em inglês | TERT promoter mutation | pt_BR |
| Palavras-chave em inglês | Transcription profiling | pt_BR |
