| Author | Saad, Maria Helena F. | |
| Author | Kritski, Afranio L. | |
| Author | Barroso, Eduardo Werneck | |
| Author | Cavalcante, Solange | |
| Author | Ferreira, Monica Antônia S. | |
| Author | Fonseca, Leila de Souza | |
| Access date | 2020-10-02T20:48:20Z | |
| Available date | 2020-10-02T20:48:20Z | |
| Document date | 1996 | |
| Citation | SAAD, Maria Helena F. et al. Use of the 2,3-diacyl-trehalose and the purified protein derivative in the serodiagnosis of tuberculosis in AIDS. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 91, n. 1, p. 97-100, Jan./Feb. 1996. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43780 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | Sorodiagnósmo | pt_BR |
| Subject in Portuguese | Infecção pelo HIV | pt_BR |
| Subject in Portuguese | AIDS | pt_BR |
| Subject in Portuguese | Ensaio de Imunoadsorção Enzimática | pt_BR |
| Title | Use of the 2,3-Diacyl-trehalose and the Purified Protein Derivative in the Serodiagnosis of Tuberculosis in AIDS | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02761996000100017 | |
| Abstract | The effect of the human immunodeficiency virus (HIV) infection on IgG production against purified protein derivative (PPD) and 2,3-diacil-trehalose (SL-IV) was investigated by an enzyme-linked immunosorbent assay (ELISA) test. Comparison between the antigens showed that immunocompetent patients produce preferentially antibodies to SL-IV than to PPD (73.3% versus 63.3%). Combination of these results showed an increase of the sensitivity to 80%, which decreased over the spectrum of immunodepression caused by HIV. In the tuberculous HIV seropositive group the sensitivities of SL-IV and PPD were 36.4% versus 40% and 0% versus 22.2% in the tuberculosis/acquired immunodeficiency syndrome (TB/AIDS) group. Combination of these results gave respectively 54.5% and 20%, showing that serological tests have limited value for diagnosis of tuberculosis in HIV infected patients. High antibody levels were observed in HIV seropositive asymptomatic group, but only two individuals were positive for both antigens. In the follow up, one of them developed tuberculous lymphadenitis, indicating that further work is needed to access the value of serological tests in predicting tuberculosis in HIV infected individuals. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Clementino Fraga Filho. Serviço de Pneumologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Serodiagnosis | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | HIV infection | pt_BR |
| Subject | PPD | pt_BR |
| Subject | SL-IV | pt_BR |
| Subject | AIDS | pt_BR |
| Subject | ELISA | pt_BR |
| DeCS | Tuberculina | pt_BR |
| e-ISSN | 1678-8060 | |
