| Author | Costa, Vanessa D. | |
| Author | Pellegrini, Patricia | |
| Author | Rotman, Vivian | |
| Author | Pittella, Ana Maria | |
| Author | Nunes, Estevão P. | |
| Author | Lago, Barbara V. | |
| Author | Lampe, Elisabeth | |
| Author | Mello, Francisco C. A. | |
| Access date | 2020-10-06T18:42:10Z | |
| Available date | 2020-10-06T18:42:10Z | |
| Document date | 2019 | |
| Citation | COSTA, Vanessa D. et al. Resistance Mutations A30K and Y93N Associated with Treatment Failure with Sofosbuvir and Daclatasvir for Hepatitis C Virus Infection Non-Responder Patients: Case Reports. Viruses, v. 11, p. 1-6, Oct. 2019. | pt_BR |
| ISSN | 1999-4915 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43836 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Title | Resistance Mutations A30K and Y93N Associated with Treatment Failure with Sofosbuvir and Daclatasvir for Hepatitis C Virus Infection Non-Responder Patients: Case Reports | pt_BR |
| Type | Article | |
| DOI | 10.3390/v11111004 | |
| Abstract | In Brazil, hepatitis C treatment has been evolving significantly with the licensing of direct-acting antivirals (DAAs). However, viral determinants (amino acid substitutions in hepatitis C virus (HCV) genome and infective genotype) associated with host factors (hepatic condition and prior HCV therapy) might limit the achievement of sustained virologic response (SVR). Here, we described two case reports in which the occurrence of HCV NS5A mutations A30K (subtype 3a) and Y93N (subtype 1a) might have influenced daclatasvir (DCV)/sofosbuvir (SOF) combined therapy non-response. Despite high response rates for DAA combined therapies in Brazil, these case reports stated the importance of an investigation about how to manage a DAA treatment failure since a combination of factors, especially the occurrence of resistance substitutions, could impact a rescue therapy with new available antivirals in clinical routine. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Serviço de Hepatologia. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Serviço de Hepatologia. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Hospital Quinta D'Or. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Subject | DAA | pt_BR |
| Subject | Hepatitis C virus (HCV) | pt_BR |
| Subject | Resistance | pt_BR |
| e-ISSN | 1999-4915 | |
