| Author | Brenière, Simone Frédérique | |
| Author | Yaksic, Nina | |
| Author | Telleria, Jenny | |
| Author | Bosseno, Marie-France | |
| Author | Noireau, François | |
| Author | Wincker, Patrick | |
| Author | Sanchez, Daniel | |
| Access date | 2020-10-08T14:03:07Z | |
| Available date | 2020-10-08T14:03:07Z | |
| Document date | 1997 | |
| Citation | BRENIÉRE, Simone Frédérique et al. Immune Response to Trypanosoma cruzi Shed Acute Phase Antigen in Children from an Endemic Area for Chagas' Disease in Bolivia. Memórias do Instituoto Oswaldo Cruz, Rio de Janeiro, v. 92, n. 4, p. 503-507, July;Aug. 1997. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43880 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Eliminar antígeno de fase aguda | pt_BR |
| Subject in Portuguese | Resposta humoral | pt_BR |
| Subject in Portuguese | Diagnóstico sorológico | pt_BR |
| Title | Immune Response to Trypanosoma cruzi Shed Acute Phase Antigen in Children from an Endemic Area for Chagas' Disease in Bolivia | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02761997000400011 | |
| Abstract | A field study of the immune response to the shed acute phase antigen (SAPA) of Trypanosoma cruzi was carried out in the locality of Mizque, Cochabamba department, Bolivia. Schoolchildren (266), with an average of 8.6 ± 3.6 years, were surveyed for parasitological and serological diagnosis, as well as antibodies directed against SAPA using the corresponding recombinant protein in ELISA. The antibodies against SAPA were shown in 82% of patients presenting positive serological diagnosis (IgG specific antibodies). The positive and negative predictive values were 0.88. Antibodies anti-SAPA were shown in 80.8% of the chagasic patients in the initial stage of the infection (positive IgM serology and/or positive buffy coat (BC) test) and in 81.4% of the patients in the indeterminate stage of the infection (positive IgG serology with negative BC and IgM tests). These results show that the anti-SAPA response is not only present during the initial stage of the infection (few months) but extends some years after infection. | pt_BR |
| Affilliation | UMR ORSTOM/CNRS nº 9926: "Génétique Moléculaire des Parasites et des Vecteurs", Casila Postal 9214, La Paz, Bolivia. | pt_BR |
| Affilliation | Universidad Mayor de San Andres. Instituto Boliviano de Biología de Altura. La Paz, Bolivia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Laboratório de Biologia Molecular e Doenças Endêmicas Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Laboratório de Biologia Molecular e Doenças Endêmicas Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Laboratório de Biologia Molecular e Doenças Endêmicas Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Laboratório de Biologia Molecular e Doenças Endêmicas Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundación Campomar. CONICET. Universidad de Buenos Aires. Buenos Aires, Argentina. | pt_BR |
| Affilliation | . | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Shed acute-phase antigen | pt_BR |
| Subject | Humoral response | pt_BR |
| Subject | Serological diagnosis | pt_BR |
| e-ISSN | 1678-8060 | |
