| Author | Melo, Christianne Bandeira | |
| Author | Cordeiro, Renato S. B. | |
| Author | Silva, Patrícia M. R. | |
| Author | Martins, Marco A. | |
| Access date | 2020-10-09T17:25:26Z | |
| Available date | 2020-10-09T17:25:26Z | |
| Document date | 1997 | |
| Citation | MELO, Christiane Bandeira et al. Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept. Memórias do Instituto Oswaldo Cruz, v. 92, Supl. 2, p. 37-43, 1997. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43905 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Eosinophil | pt_BR |
| Subject in Portuguese | Inflamação e pleurisia | pt_BR |
| Subject in Portuguese | Prostaglandinas | pt_BR |
| Subject in Portuguese | Alergia | pt_BR |
| Title | Modulatory Role of Eosinophils in Allergic Inflammation: New Evidence for a Rather Outdated Concept | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02761997000800007 | |
| Abstract | The eosinophilic response has been identified as a key alteration in the pathogenesis of asthma and other allergic diseases. A close-correlation between disease severity and eosinophilia, and the eosinophil ability to provide toxic and pro-inflammatory agents are the major elements supporting the interpretation that there is indeed a causal relationship between these phenomena. Nevertheless, controversy still persists since some studies have clearly demonstrated that eosinophil infiltration is not necessarily accompanied by tissue damage or hyperresponsiveness. In addition, there are some examples in the literature in which such alterations are not modified following abrogation of eosinophil influx. In this review it will be argued, based on a model of IgE-dependent pleurisy, that eosinophil infiltration can be associated with down-regulation of allergic inflammatory response. The potential mechanism by which eosinophils could be acting as a immunomodulatory cells in this particular system will also be assessed. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Eosinophil | pt_BR |
| Subject | Prostaglandins | pt_BR |
| Subject | Allergy | pt_BR |
| Subject | Inflammation and pleurisy | pt_BR |
| e-ISSN | 1678-8060 | |
