Author | Diaz, Bruno L. | |
Author | Serra, Magda F. | |
Author | Barreto, Emiliano O. | |
Author | Cordeiro, Renato S. B. | |
Author | Martins, Marco A. | |
Author | Silva, Patrícia M. R. e | |
Access date | 2020-10-10T13:10:32Z | |
Available date | 2020-10-10T13:10:32Z | |
Document date | 1997 | |
Citation | DIAZ, Bruno L. et al. Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormones. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Suppl. 2, p. 219-222, 1997. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/43916 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Diabetes | pt_BR |
Subject in Portuguese | Pleurisia alérgica | pt_BR |
Subject in Portuguese | Mastócitos | pt_BR |
Subject in Portuguese | Eosinophils | pt_BR |
Subject in Portuguese | Corticosteróides | pt_BR |
Title | Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormone | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/S0074-02761997000800031 | |
Abstract | Previous studies have evidenced for the existence of interactive regulatory mechanisms between insulin and steroid hormones in different systems. In this study, we have investigated whether endogenous corticosteroids could be implicated in the hyporeactivity to antigen challenge observed in sensitized diabetic rats. Alloxinated rats showed a long-lasting increase in the blood glucose levels and a reduction in the number of pleural mast cells at 48 and 72 hr, but not at 24 hr after alloxan administration. In parallel, they also showed a significant elevation in the plasma levels of corticosterone together with an increase in the adrenal/body weight ratio. Antigen-evoked eosinophil accumulation appeared significantly reduced in rats pretreated with dexamethasone as well as in those rendered diabetic 72 hr after alloxan. In the same way, naive animals treated with dexamethasone also responded with a significant decrease in the number of pleural mast cells. Interestingly, when sensitized diabetic rats were pretreated with the steroid antagonist RU 38486 a reversion of the reduction in the allergen-induced eosinophil accumulation was noted. We conclude that the down-regulation of the allergic inflammatory response in diabetic rats is close-related to reduction in mast cell numbers and over expression of endogenous corticosteroids. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Diabetes | pt_BR |
Subject | Allergic pleurisy | pt_BR |
Subject | Mast cells | pt_BR |
Subject | Eosinophils | pt_BR |
Subject | Corticosteroids | pt_BR |
e-ISSN | 1678-8060 | |