| Author | Agwale, Simon M. | |
| Author | Duhlinska, Dockha D. | |
| Author | Grimaldi Jr., Gabriel | |
| Access date | 2020-10-11T19:15:50Z | |
| Available date | 2020-10-11T19:15:50Z | |
| Document date | 1998 | |
| Citation | AGWALE, Simon M.; DUHLINSKA, Dockha; GRIMALDI JR., Gabriel. Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 93, n. 1, p. 23-27, Jan./Feb. 1998. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43919 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmaniose | pt_BR |
| Subject in Portuguese | Leishmaniose cutânea | pt_BR |
| Subject in Portuguese | Imunoprevalência | pt_BR |
| Subject in Portuguese | Leishmania maior | pt_BR |
| Subject in Portuguese | Nigéria | pt_BR |
| Title | Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria - Discovery of a New Focus | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02761998000100005 | |
| Abstract | A pilot study was undertaken to preliminary illustrate the leishmanin skin test (LST) positivity to distinct antigen preparations (derived from promastigote of either Leishmania major or L. amazonensis, or pooled L. mexicana, L. amazonensis and L. guyanensis) in cutaneous leishmaniasis (CL) patients and healthy subjects living in two endemic foci in Nigeria. The study was designed to provide insights into whether cross-species leishmanin, such as that prepared from New World Leishmania could be useful to detect cases of Old World leishmanial infection and to compare the results with LST using L. major-derived leishmanin. The overall LST positivity in individuals from Keana tested with the cross-species leishmanin was 28.7% (27/94), while the positivity rate in the subjects from Kanana tested with the same leishmanin was 54.5% (6/11). Lower positivity values were obtained when L. major (12.5%; 11/88) or L. amazonensis (15.8%; 9/57) was tested as antigen in grossly comparable populations. Moreover, the pooled leishmanin identified most of the subjects (13/14; 92.9%) with active or healed CL, and the maximum reaction sizes were found among positive subjects in this group. No healthy controls (10 total) showed specific DTH response. The LST was useful for assessing the prevalence of subclinical infection and for measuring CL transmission over time. We report for the first time the occurrence of CL in Kanana village of Langtang South local government area of Plateau State. | pt_BR |
| Affilliation | University of Jos. Department of Zoology. Jos, Plateau State, Nigeria. | pt_BR |
| Affilliation | University of Jos. Department of Zoology. Jos, Plateau State, Nigeria. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leishmaniasis | pt_BR |
| Subject | Cutaneous leishmaniasis | pt_BR |
| Subject | Leishmania major | pt_BR |
| Subject | immunoprevalence | pt_BR |
| Subject | Nigeria | pt_BR |
| e-ISSN | 1678-8060 | |
