| Author | Pacheco, Raquel S. | |
| Author | Ferreira, Marcelo S. | |
| Author | Machado, Maria Inês | |
| Author | Brito, Célia M. M. | |
| Author | Pires, Marize Q. | |
| Author | Cruz, Alda M. da | |
| Author | Coutinho, Sergio G. | |
| Access date | 2020-10-11T20:23:31Z | |
| Available date | 2020-10-11T20:23:31Z | |
| Document date | 1998 | |
| Citation | PACHECO, Raquel S. et al. Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 93, n. 2, p. 185-169, Mar./Apr. 1998. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43924 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Infecção oportunista | pt_BR |
| Subject in Portuguese | Co-infecção por AIDS | pt_BR |
| Subject in Portuguese | Reativação | pt_BR |
| Title | Chagas Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02761998000200005 | |
| Abstract | In the past few years, new aspects of the immunopathology of Chagas’ disease have been described
in immunosuppressed patients, such as fatal central nervous system lesions related to the reactivation of
the parasite. This article is the first description of the genotypic characterization, at the strain level, of
Trypanosoma cruzi isolated from a patient with Chagas‘ disease/AIDS co-infection. The presence of
four hypodense lesions was observed in the cranial compute tomographic scan. The diagnosis of AIDS
was assessed by the detection of anti-HIV antibodies using enzyme-linked immunosorbent assay (ELISA)
and Western blot techniques. The CD4+ lymphocyte counts were maintained under 200 cells/mm3 during one year demonstrating the severity of the state of immunosuppression. Chagas’ disease was confirmed by serological and parasitological methods. Trypomastigote forms were visualized in a thick
blood smear. The parasite isolated is genotypically similar to the CL strain. The paper reinforces that
cerebral Chagas’ disease can be considered as another potential opportunistic infection in AIDS resulting from the reactivation of a dormant T. cruzi infection acquired years earlier. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Departamento de Patologia. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Departamento de Patologia. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Publica Sérgio Arouca. Departamento de Ciências Biológicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Chagas’ disease | pt_BR |
| Subject | AIDS co-infection | pt_BR |
| Subject | Opportunistic infection | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Reactivation | pt_BR |
| e-ISSN | 1678-8060 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
