| Author | Cupolillo, Elisa | |
| Author | Momen, Hooman | |
| Author | Grimaldi Jr., Gabriel | |
| Access date | 2020-10-12T18:20:13Z | |
| Available date | 2020-10-12T18:20:13Z | |
| Document date | 1998 | |
| Citation | CUPOLILLO, Elisa; MOMEN, Hooman; GRIMALDI JR., Gabriel. Genetic Diversity in Natural Populations of New World Leishmania. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 5, p. 663-668, Sept./Oct. 1998. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43946 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmaniose | pt_BR |
| Subject in Portuguese | Leishmania do Novo Mundo | pt_BR |
| Subject in Portuguese | Epidemiologia | pt_BR |
| Subject in Portuguese | Molecular caracterização | pt_BR |
| Title | Genetic Diversity in Natural Populations of New World Leishmania | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02761998000500018 | |
| Abstract | Our results have shown the wide diversity of parasites within New World Leishmania. Biochemical and molecular characterization of species within the genus has revealed that much of the population heterogeneity has a genetic basis. The source of genetic diversity among Leishmania appears to arise from predominantly asexual, clonal reproduction, although occasional bouts of sexual reproduction can not be ruled out. Genetic variation is extensive with some clones widely distributed and others seemingly unique and localized to a particular endemic focus. Epidemiological studies of leishmaniasis has been directed to the ecology and dynamics of transmission of Leishmania species/variants, particularly in localized areas. Future research using molecular techniques should aim to identify and follow Leishmania types in nature and correlate genetic typing with important clinical characteristics such as virulence, pathogenicity, drug resistance and antigenic variation. The epidemiological significance of such variation not only has important implications for the control of the leishmaniases, but would also help to elucidate the evolutionary biology of the causative agents. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Laboratório de Sistemática Bioquímica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | New World Leishmania | pt_BR |
| Subject | Leishmaniasis | pt_BR |
| Subject | Epidemiology | pt_BR |
| Subject | Molecular characterization | pt_BR |
| e-ISSN | 1678-8060 | |
