| Author | Ferraz, Sheila N. | |
| Author | Costa, Gabriela F. | |
| Author | Carneiro Neto, José Abraão | |
| Author | Hebert, Thiago | |
| Author | Oliveira, Cassius J. V. de | |
| Author | Guerra, Mariele | |
| Author | Oliveira, Lívia M. A. | |
| Author | Carvalho, Edgar Marcelino de. | |
| Access date | 2020-10-14T13:48:54Z | |
| Available date | 2020-10-14T13:48:54Z | |
| Document date | 2020 | |
| Citation | FERRAZ, Sheila N. et al. Neurologic, clinical, and immunologic features in a cohort of HTLV-1 carriers with high proviral loads. Journal of NeuroVirology, v. 26, p. 520-529, 8 May 2020. | pt_BR |
| ISSN | 1538-2443 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/43983 | |
| Sponsorship | Conselho Nacional de Pesquisa (CNPq), Ministério de Ciência e Tecnologia, Fundação Maria Emília Freire Pedreira de Carvalho. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Mielopatia associada ao HTLV-1 | pt_BR |
| Subject in Portuguese | HTLV-1 | pt_BR |
| Subject in Portuguese | Portadores de HTLV-1 | pt_BR |
| Subject in Portuguese | Mielopatia | pt_BR |
| Title | Neurologic, clinical, and immunologic features in a cohort of HTLV-1 carriers with high proviral loads | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1007/s13365-020-00847-y | pt_BR |
| Abstract | A high proviral load (PVL) is recognized as a risk factor for human T cell leukemia virus-1-associated myelopathy/tropical
spastic paraparesis (HAM/TSP), but there is a lack of prospective studies evaluating whether or not HTLV-1 carriers with high
PVL are at risk of developing HAM/TSP or other HTLV-1-related diseases. Here, we compare the incidence of clinical manifestations
and the cytokine levels in 30 HTLV-1 carriers with high (> 50,000 copies/106 PBMC) and an equal number of subjects
with low proviral load. Participants were followed for 3 to 16 years (median of 11 years). The PVL, IFN-γ, TNF, and IL-10 levels
were quantified at entry and at the end of the follow-up. Among the self-reported symptoms in the initial evaluation, only the
presence of paresthesia on the hands was more frequent in the group with high PVL (p < 0.04). The production of IFN-γ was
higher in the group with high PVL group (median of 1308 versus 686 pg/ml, p < 0.011) when compared with the control group in
the first assessment. There was no difference in the occurrence of urinary symptoms or erectile dysfunction, periodontal disease,
Sicca syndrome, and neurologic signs between the two groups during the follow-up. The observation that none of the HTLV-1
carriers with high PVL and with exaggerated inflammatory response progressed to HAM/TSP indicates that other factors in
addition to the PVL and an exaggerated immune response are involved in the pathogenesis of HAM/TSP. | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science and Technology in Tropical Diseases. Salvador, BA, Brazil. | pt_BR |
| Subject | HTLV-1-associated myelopathy | pt_BR |
| Subject | HTLV-1 | pt_BR |
| Subject | Proviral load | pt_BR |
| Subject | HTLV-1 carriers | pt_BR |
| Subject | Myelopathy | pt_BR |
