| Author | Pinto, Luzia M. O | |
| Author | Oliveira, Solange A. | |
| Author | Braga, Elzinandes L. A. | |
| Author | Nogueira, R. M. R. | |
| Author | Kubelka, Claire F. | |
| Access date | 2020-10-16T19:14:08Z | |
| Available date | 2020-10-16T19:14:08Z | |
| Document date | 1999 | |
| Citation | PINTO, Luzia M. O. et al. Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 3, p. 387-394, May/June 1999. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44021 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Dengue | pt_BR |
| Subject in Portuguese | Fator de necrose tumoral a | pt_BR |
| Subject in Portuguese | Interleukin 6 | pt_BR |
| Subject in Portuguese | Necrose tumoral solúvel | pt_BR |
| Subject in Portuguese | Fator de receptor | pt_BR |
| Title | Increased Pro-inflammatory Cytokines (TNF-a and IL-6) and Anti-inflammatory Compounds (sTNFRp55 and sTNFRp75) in Brazilian Patients during Exanthematic Dengue Fever | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02761999000300019 | |
| Abstract | Pro-inflammatory cytokines, tumor necrosis factor (TNF-a), interleukin-6 (IL-6) and interleukin-1b (IL-1b) as well as anti-inflammatory compounds, soluble TNF-Receptor p55 (sTNFRp55), sTNFRp75 and IL-1 receptor antagonist (sIL-1Ra), were investigated in 34 Brazilian cases of dengue fever (DF) originated from a study of exanthematic virosis. The presence of pro-inflammatory cytokines was detected in sera from these patients by ELISA. TNF-a and IL-6 levels were significantly higher than control subjects in 32% and 52% patients, respectively. To our knowledge this was the first time a receptor antagonist and soluble receptors for cytokines were detected in sera obtained during exanthematic DF without hemorrhagic manifestations. Both sTNFRp55 and sTNFRp75 were consistently elevated in 42% and 84% patients, respectively. Most patients had IL-1b levels not different from those of normal subjects, except for one case. Only 16% patients had altered levels of IL-1Ra. Previous studies in dengue hemorrhagic fever patients demonstrated production of these soluble factors; here we observed that they are found in absence of hemorrhagic manifestations. The possible role of these anti-inflammatory compounds in immune cell activation and in regulating cytokine-mediated pathogenesis during dengue infection is discussed. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Disciplina de Doenças Infecto-Parasitárias. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Dengue | pt_BR |
| Subject | Tumor necrotis factor a | pt_BR |
| Subject | Interleukin 6 | pt_BR |
| Subject | Soluble tumor necrosis | pt_BR |
| Subject | Factor receptor | pt_BR |
| e-ISSN | 1678-8060 | |
