| Author | Araujo, Catarina A.. C. | |
| Author | Alegrio, Leila V. | |
| Author | Gomes, Denise C. F. | |
| Author | LIma, Marco Edilson F. | |
| Author | Cardoso, Leonardo Gomes | |
| Author | Leon, Leonor L. | |
| Access date | 2020-10-17T19:10:39Z | |
| Available date | 2020-10-17T19:10:39Z | |
| Document date | 1999 | |
| Citation | ARAUJO, Catarina A. C. et al. Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 6, p. 791-794, Nov./Dec, 1999. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44033 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmania amazonensi | pt_BR |
| Subject in Portuguese | Centrolobium sclerophyllum | pt_BR |
| Subject in Portuguese | Diarilheptanoides | pt_BR |
| Title | Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02761999000600015 | |
| Abstract | In a previous work we demonstrated that diarylheptanoids extracted from Centrolobium
sclerophyllum are very active against Leishmania amazonensis promastigotes. In order to continue our
studies with these class of compounds, we decided to evaluate the activity of several diarylheptanoids
derived from curcumin (diferuloyl methane) against the extracellular form (promastigotes) of L.
amazonensis. Furthermore, an experiment against the intracellular form of the parasite (amastigotes)
was carried out, comparing the most active compound among the curcumin derivatives (the
methylcurcumin) with des-O-methylcentrolobine, the most active diarylheptanoid derived from C.
sclerophyllum. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Departamento de Química. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Departamento de Química. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Departamento de Química. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leishmania amazonensi | pt_BR |
| Subject | Centrolobium sclerophyllum | pt_BR |
| Subject | Diarylheptanoids | pt_BR |
| e-ISSN | 1678-8060 | |
