| Author | Carvalho, Leonardo J. M . | |
| Author | Oliveira, Salma G. | |
| Author | Alves, Francisco A. | |
| Author | Brígido, Maria C. O . | |
| Author | Muniz, José A. P. C. | |
| Author | Ribeiro, Claudio Tadeu Daniel | |
| Access date | 2020-10-19T18:09:03Z | |
| Available date | 2020-10-19T18:09:03Z | |
| Document date | 2000 | |
| Citation | CARVALHO, Lonardo J. M. et al. Aotus infulatus Monkey is Susceptible to Plasmodium falciparum Infection and May Constitute an Alternative Experimental Model for Malaria. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 95, n. 3, p. 363-365, May/June 2000. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44063 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Aotus infulatus | pt_BR |
| Subject in Portuguese | Plasmodium falciparum | pt_BR |
| Subject in Portuguese | Malária | pt_BR |
| Subject in Portuguese | Modelo primata | pt_BR |
| Title | Aotus infulatus Monkey is Susceptible to Plasmodium falciparum Infection and May Constitute an Alternative Experimental Model for Malaria | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02762000000300011 | |
| Abstract | Aotus is one of the WHO-recommended primate models for studies in malaria, and several species
can be infected with Plasmodium falciparum or P. vivax. Here we describe the successful infection of the
species A. infulatus from eastern Amazon with blood stages of P. falciparum. Both intact and splenectomized animals were susceptible to infection; the intact ones were able to keep parasitemias at lower
levels for several days, but developed complications such as severe anemia; splenectomized monkeys
developed higher parasitemias but no major complications. We conclude that A. infulatus is susceptible
to P. falciparum infection and may represent an alternative model for studies in malaria. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Nacional de Saúde. Instituto Evandro Chagas. Serviço de Parasitologia. Belém, PA, Brasil. | pt_BR |
| Affilliation | Centro Nacional de Primatas, FNS. Ananindeua, PA, Brasil. | pt_BR |
| Affilliation | Centro Nacional de Primatas, FNS. Ananindeua, PA, Brasil. | pt_BR |
| Affilliation | Centro Nacional de Primatas, FNS. Ananindeua, PA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Aotus infulatus | pt_BR |
| Subject | Plasmodium falciparum | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Primate model | pt_BR |
| e-ISSN | 1678-8060 | |
