| Author | Guimarães, M. L. | |
| Author | Moreira, A. S. | |
| Author | Morgado, M. G. | |
| Access date | 2020-10-26T13:01:57Z | |
| Available date | 2020-10-26T13:01:57Z | |
| Document date | 2002 | |
| Citation | GUIMARÃES, M. L; MOREIRA, A. S.; MORGADO, M. G. Polymorphism of the Human Immunodeficiency Virus Type 1 in Brazil: Genetic Characterization of the nef Gene and Implications for Vaccine Design. Memórias do instituto Oswaldo Cruz, Rio de Janeiro, v. 97, n. 4, p. 523-526, June 2002. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44187 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Gene nef | pt_BR |
| Subject in Portuguese | Polimorfismo HIV-1 | pt_BR |
| Subject in Portuguese | Vacina HIV/AIDS | pt_BR |
| Subject in Portuguese | Epítopos de células B e CTL nef | pt_BR |
| Title | Polymorphism of the Human Immunodeficiency Virus Type 1 in Brazil: Genetic Characterization of the nef Gene and Implications for Vaccine Design | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02762002000400013 | |
| Abstract | Most of the Brazilian HIV-1 samples have been characterized based on the structural genes (env, gag and pol)
and no data concerning the variability of the accessory genes such as nef have been available so far. Considering
the role of the nef on virus biology and the inclusion of this region in some HIV/AIDS vaccine products under testing,
the purpose of this study was to document the genetic diversity of the nef gene in third-four HIV-1 Brazilian samples
previously subtyped based on the env C2-V3 region. Although only few non-subtype B samples have already been
analyzed so far, the cytotoxic Tlymphocyte epitopes encoded in this region were relatively conserved among the
subtypes, with some amino acid signatures mainly in the subtype C samples. Considering the increasing of the nonB HIV-1 subtypes worldwide, in special the subtype C, more data should be generated concerning the genetic and
antigenic variability of these subtypes, as well as the study of the impact of such polymorphism in HIV/AIDS vaccine
design and testing. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Nef gene | pt_BR |
| Subject | HIV-1 polymorphism | pt_BR |
| Subject | HIV/AIDS vaccine | pt_BR |
| Subject | B cell and CTL nef epitopes | pt_BR |
| e-ISSN | 1678-8060 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
