| Author | Quadros, Claudio Almeida | |
| Author | Leal, Maria Carolina Bezerra Di Medeiros | |
| Author | Baptista Sobrinho, Carlos de Almeida | |
| Author | Nonaka, Carolina Kymie Vasques | |
| Author | Souza, Bruno Solano de Freitas | |
| Author | Mattos, Juliana Cristina Milan | |
| Author | Catai, Aparecida Maria | |
| Author | Di Lorenzo, Valéria Amorim Pires | |
| Author | Ferreira, Antonio Gilberto | |
| Access date | 2020-10-28T12:26:42Z | |
| Available date | 2020-10-28T12:26:42Z | |
| Document date | 2020 | |
| Citation | QUADROS, Claudio Almeida et al. Preclinical validation of occupational and environmental safety of an isolation system for non-invasive ventilation in COVID-19 and other aerosol-transmitted infections. Expert Review of Medical Devices, p. 1-20, 2020. | |
| ISSN | 1743-4440 | |
| URI | https://www.arca.fiocruz.br/handle/icict/44241 | |
| Sponsorship | Laboratory of Nuclear Magnetic Resonance, Department of Chemistry, São Carlos Federal University and the Center for Biotechnology and Cell Therapy, São Rafael Hospital, D'Or Institute for Research and Education. | |
| Language | eng | en_US |
| Publisher | Expert Reviews | |
| Rights | open access | |
| Subject in Portuguese | Infecção respiratória ocupacional | pt_BR |
| Subject in Portuguese | Dispositivos de isolamento infecção respiratória | pt_BR |
| Subject in Portuguese | COVID-19 | pt_BR |
| Subject in Portuguese | Gripe | pt_BR |
| Subject in Portuguese | Oxigênio de alto fluxo | pt_BR |
| Subject in Portuguese | Pressão positiva contínua nas vias aéreas | pt_BR |
| Title | Preclinical validation of occupational and environmental safety of an isolation system for non-invasive ventilation in COVID-19 and other aerosol-transmitted infections | en_US |
| Type | Preprint | |
| DOI | 10.1080/17434440.2020.1842190 | |
| Abstract | Current SARS-CoV-2 pandemic has provoked the collapse of some health systems due to insufficient intensive care unit capacity. The use of continuous positive airway pressure (CPAP) and highflow nasal oxygen (HFNO) therapies have been limited in consideration of the risk of occupational infection in healthcare professionals. Aims: In preclinical experimental simulations, evaluate occupational and environmental safety of the newly developed isolation system for aerosol transmitted infections (ISATI). Method: Simulations were conducted to test ISATI’s capability to isolate aerosolized molecular (caffeine), and biological (SARS-CoV-2 synthetic RNA) markers. Caffeine deposition was analyzed on nitrocellulose sensor discs by proton nuclear magnetic resonance spectroscopy. Synthetic SARS-CoV-2 detection was performed by reverse transcription polymerase chain reaction. Results: ISATI demonstrated efficacy in isolating molecular and biological markers within the enclosed environment in simulated conditions of CPAP, HFNO and mechanical ventilation therapy. Neither the molecular marker nor substantial amounts of synthetic SARS-CoV-2 RNA were detected in the surrounding environment, outside ISATI, indicating appropriate occupational safety for healthcare professionals. Conclusion: Aerosolized markers were successfully contained within ISATI in all experimental simulations, offering occupational and environmental protection against the dissemination of aerosolized microparticles under CPAP or HFNO therapy conditions, which are indicated for patients with acute respiratory infections. | en_US |
| Affilliation | Bahia State University. Medical School. Department of Life Sciences. Salvador, BA, Brazil. | |
| Affilliation | São Carlos Federal University. Department of Chemistry. São Carlos, SP, Brazil. | |
| Affilliation | University Center of Planalto Central Aparecido dos Santos. Brasília, DF, Brazil. | |
| Affilliation | Central for Biotechnology and Cell Therapy, São Rafael Hospital. Salvador, BA, Brazil / D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | |
| Affilliation | Central for Biotechnology and Cell Therapy, São Rafael Hospital. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | São Carlos Federal University. Department of Physiotherapy. São Carlosw, SP, Brazil. | |
| Affilliation | São Carlos Federal University. Department of Physiotherapy. São Carlosw, SP, Brazil. | |
| Affilliation | São Carlos Federal University. Department of Chemistry. São Carlos, SP, Brazil. | |
| Subject | Occupational respiratory infection | en_US |
| Subject | Isolation devices respiratory infection | en_US |
| Subject | COVID-19 | en_US |
| Subject | Influenza | en_US |
| Subject | High-flow oxygen | en_US |
| Subject | Continuous positive airway pressure | en_US |
