| Author | Cardoso, Rafael M. | |
| Author | Santos, Robson O. dos | |
| Author | Munoz, Rodrigo A. A. | |
| Author | Garcia, Carlos D. | |
| Author | Blanes, Lucas | |
| Access date | 2020-10-29T20:01:21Z | |
| Available date | 2020-10-29T20:01:21Z | |
| Document date | 2020 | |
| Citation | CARDOSO, Rafael M. et al. A multi-pump magnetohydrodynamics lab-on-a-chip device for automated flow control and analyte delivery. Sensors. v. 20, n. 4909, p. 1-9, 2020. | pt_BR |
| ISSN | 1424-8220 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44267 | |
| Language | por | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | pt_BR |
| Title | A multi-pump magnetohydrodynamics lab-on-a-chip device for automated flow control and analyte delivery | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3390/s20174909 | |
| Abstract | This article shows the development of a computer-controlled lab-on-a-chip device with three magnetohydrodynamic (MHD) pumps and a pneumatic valve. The chip was made of a stack of layers of polymethylmethacrylate (PMMA), cut using a laser engraver and thermally bonded.
The MHD pumps were built using permanent magnets (neodymium) and platinum electrodes, all of them controlled by an Arduino board and a set of relays. The implemented pumps were able to drive solutions in the open channels with a flow rate that increased proportionally with the channel width and applied voltage. To address the characteristic low pressures generated by this kind of pump, all channels were interconnected. Because the electrodes were immersed in the electrolyte, causing electrolysis and pH variations, the composition and ionic strength of the electrolyte solution were controlled. Additionally, side structures for releasing bubbles were integrated. With this multi-pump and valve solution, the device was used to demonstrate the possibility of performing an injection sequence in a system that resembles a traditional flow injection analysis system. Ultimately, the results demonstrate the possibility of performing injection sequences using an array of MHD pumps that can perform fluid handling in the 0–5 µL s−1 range. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Química. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Química. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Department of Chemistry. Clemson University. Clemson, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. | pt_BR |
| Subject | Magnetohydrodynamic | pt_BR |
| Subject | Hydrodynamic Models | pt_BR |
| Subject | Lab-On-A-Chip Devices | pt_BR |
| Subject | Flow Injection Analysis | pt_BR |
| Subject in Spanish | Modelos Hidrodinámicos | pt_BR |
| Subject in Spanish | Dispositivos Laboratorio en un Chip | pt_BR |
| Subject in Spanish | Análisis de Inyección de Flujo | pt_BR |
| Subject in French | Modèles Hydrodynamiques | pt_BR |
| Subject in French | Laboratoires sur puces | pt_BR |
| Subject in French | Analyse par injection en flux continu | pt_BR |
| DeCS | Modelos Hidrodinâmicos | pt_BR |
| DeCS | Dispositivos Lab-On-A-Chip | pt_BR |
| DeCS | Análise de Injeção de Fluxo | pt_BR |
