| Author | Nassar Junior, Antonio Paulo | |
| Author | Trevisani, Mariane da Silva | |
| Author | Bettim, Barbara Beltrame | |
| Author | Zampieri, Fernando Godinho | |
| Author | Carvalho Jr, José Albani | |
| Author | Silva Jr, Amilton | |
| Author | Freitas, Flávio Geraldo Rezende de | |
| Author | Pinto, Jorge Eduardo da Silva Soares | |
| Author | Romano, Edson | |
| Author | Ramos, Silvia Regina | |
| Author | Faria, Guilherme Brenande Alves | |
| Author | Andrade-E-Silva, Ulysses V. | |
| Author | Santos, Robson Correa | |
| Author | Tommasi, Edmundo de Oliveira | |
| Author | Moraes, Ana Paula Pierre de | |
| Author | Cruz, Bruno Azevedo da | |
| Author | Bozza, Fernando A. | |
| Author | Caruso, Pedro | |
| Author | Salluh, Jorge Ibrahin Figueira | |
| Author | Soares, Marcio | |
| Access date | 2020-10-31T18:59:38Z | |
| Available date | 2020-10-31T18:59:38Z | |
| Document date | 2020 | |
| Citation | NASSAR JUNIOR, Antonio Paulo et al. Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country. PloS One, v. 15, n. 8, p. 1-10, 2020. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44294 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Title | Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pone.0238124 | |
| Abstract | Background: Very elderly critically ill patients (ie, those older than 75 or 80 years) are an increasing population in intensive care units. However, patients with cancer have encompassed only a minority in epidemiological studies of very old critically-ill patients. We aimed to describe clinical characteristics and identify factors associated with hospital mortality in a cohort of patients aged 80 or older with cancer admitted to intensive care units (ICUs).
Methods: This was a retrospective cohort study in 94 ICUs in Brazil. We included patients aged 80 years or older with active cancer who had an unplanned admission. We performed a mixed effect logistic regression model to identify variables independently associated with hospital mortality.
Results: Of 4604 included patients, 1807 (39.2%) died in hospital. Solid metastatic (OR = 2.46; CI 95%, 2.01-3.00), hematological cancer (OR = 2.32; CI 95%, 1.75-3.09), moderate/severe performance status impairment (OR = 1.59; CI 95%, 1.33-1.90) and use of vasopressors (OR = 4.74; CI 95%, 3.88-5.79), mechanical ventilation (OR = 1.54; CI 95%, 1.25-1.89) and renal replacement (OR = 1.81; CI 95%, 1.29-2.55) therapy were independently associated with increased hospital mortality. Emergency surgical admissions were associated with lower mortality compared to medical admissions (OR = 0.71; CI 95%, 0.52-0.96).
Conclusions: Hospital mortality rate in very elderly critically ill patients with cancer with unplanned ICU admissions are lower than expected a priori. Cancer characteristics, performance status impairment and acute organ dysfunctions are associated with increased mortality. | pt_BR |
| Affilliation | A.C. Camargo Cancer Center. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | A.C. Camargo Cancer Center. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | A.C. Camargo Cancer Center. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | ID'Or Research and Education Institute. São Paulo, SP, Brazil / Hospital do Coração. Research Institute. São Paulo, SP, Brazil / University of Odense. Center for Epidemiological and Clinical Research. Odense, Denmark. | pt_BR |
| Affilliation | Hospital São Luiz. Rede D'Or. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Hospital Alemão Oswaldo Cruz. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Hospital Sepaco. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Hospital Norte D'Or. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital do Coração. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Hospital São Luiz. Unidade Assunção. São Bernardo do Campo, SP, Brasil. | pt_BR |
| Affilliation | Hospital Oeste D'Or. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Pio XII. Hospital de Câncer de Barretos. Barretos, SP, Brasil. | pt_BR |
| Affilliation | Hospital Estadual Adão Pereira Nunes. Duque de Caxias, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Israelita Albert Sabin. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital de Câncer do Maranhão Tarquínio Lopes Filho. São Luís, MA, Brasil. | pt_BR |
| Affilliation | Instituto Nacional de Câncer-HC II. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | A.C. Camargo Cancer Center. São Paulo, SP, Brasil / University of São Paulo. Heart Institute. Discipline of Pulmonology. São Paulo, SP, Brazil. | pt_BR |
| Affilliation | Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Renal cancer | pt_BR |
| Subject | Intensive care units | pt_BR |
| Subject | Prostate cancer | pt_BR |
| Subject | Breast cancer | pt_BR |
| Subject | Geriatric care | pt_BR |
