| Author | Cubillos-Angulo, Juan Manuel | |
| Author | Vinhaes, Caian L. | |
| Author | Fukutani, Eduardo R. | |
| Author | Albuquerque, Victor V. S. | |
| Author | Queiroz, Artur Trancoso Lopo de | |
| Author | Andrade, Bruno de Bezerril | |
| Author | Fukutani, Kiyoshi Ferreira | |
| Access date | 2020-11-03T12:43:55Z | |
| Available date | 2020-11-03T12:43:55Z | |
| Document date | 2020 | |
| Citation | CUBILLOS-ANGULO, Juan Manuel et al. In silico transcriptional analysis of mRNA and miRNA reveals unique biosignatures that characterizes different types of diabetes. Plos One, p. 1-17, Sept. 2020. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44297 | |
| Sponsorship | Intramural Program of Fundac¸ão Oswaldo Cruz
(FIOCRUZ) and by the Brazilian National Council for
Scientific and Technological Development (CNPq).
K.F.F. received a fellowship from the Programa Nacional de Po´s-Doutorado, Coordenac¸ão de
Aperfeic¸oamento de Pessoal de Nı´vel Superior
(CAPES) (Finance Code 001). The work of B.B.A.
was supported by grants from the NIH
(U01AI115940, R01AI069923-08, R01AI20790-
02). BBA and A.T.L.Q are senior investigators from
CNPq. J. M. C-A. was supported by the
Organization of American States - Partnerships
Program for Education and Training (OAS-PAEC)
and Coordenac¸ão de Aperfeic¸oamento de Pessoal
de Nı´vel Superior (CAPES) (Finance Code 001). C.
L.V. is a research fellow from CNPq. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Diabetes | pt_BR |
| Subject in Portuguese | Saúde pública | pt_BR |
| Subject in Portuguese | MicroRNAs | pt_BR |
| Subject in Portuguese | Estado Pré-Diabético | pt_BR |
| Title | In silico transcriptional analysis of mRNA and miRNA reveals unique biosignatures that characterizes different types of diabetes | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pone.0239061 | |
| Abstract | Diabetes (DM) has a significant impact on public health. We performed an in silico study of
paired datasets of messenger RNA (mRNA) micro-RNA (miRNA) transcripts to delineate
potential biosignatures that could distinguish prediabetes (pre-DM), type-1DM (T1DM) and
type-2DM (T2DM). Two publicly available datasets containing expression values of mRNA
and miRNA obtained from individuals diagnosed with pre-DM, T1DM or T2DM, and normoglycemic
controls (NC), were analyzed using systems biology approaches to define combined
signatures to distinguish different clinical groups. The mRNA profile of both pre-DM
and T2DM was hallmarked by several differentially expressed genes (DEGs) compared to
NC. Nevertheless, T1DM was characterized by an overall low number of DEGs. The miRNA
signature profiles were composed of a substantially lower number of differentially expressed
targets. Gene enrichment analysis revealed several inflammatory pathways in T2DM and
fewer in pre-DM, but with shared findings such as Tuberculosis. The integration of mRNA
and miRNA datasets improved the identification and discriminated the group composed by
pre-DM and T2DM patients from that constituted by normoglycemic and T1DM individuals.
The integrated transcriptomic analysis of mRNA and miRNA expression revealed a unique
biosignature able to characterize different types of DM. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, BA, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, BA, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, BA, Brazil. | pt_BR |
| Subject | Diabetes | pt_BR |
| Subject | Health public | pt_BR |
| Subject | MicroRNAs | pt_BR |
| Subject | Prediabetic State | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
