Author | Alves, Luciana Vignólio | |
Author | Temporal, Rosane Maria | |
Author | Cysne-Finkelstein, Léa | |
Author | Leon, Leonor Laura | |
Access date | 2020-11-13T19:27:26Z | |
Available date | 2020-11-13T19:27:26Z | |
Document date | 2003 | |
Citation | ALVES, Luciana Vignólio et al. Efficacy of a diarylheptanoid derivative against Leishmania amazonensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 4, p. 553-555, June 2003. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/44404 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmania amazonensis | pt_BR |
Subject in Portuguese | Leishmaniose | pt_BR |
Subject in Portuguese | Ensaio de tratamento | pt_BR |
Subject in Portuguese | Diarilheptanoide | pt_BR |
Title | Efficacy of a diarylheptanoid derivative against Leishmania amazonensis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/S0074-02762003000400024 | |
Abstract | The activity of several diarylheptanoid derivatives (curcuminoids) was previously evaluated against Leishmania amazonensis promastigotes and among them the most active compound was the [1-(4-methoxy-phenyl)-7-(3,4-
methoxy-4-hydroxy-phenyl)-1,6-heptadien-3, 5-dione]. This derivative was chosen to be assayed in vivo in a treatment trial. For these experiments, the curcuminoid compound was used in a concentration equivalent to the IC50/
24 h, obtained from the previous study. Balb/c mice were inoculated subcutaneously in the footpad with L. amazonensis
infective promastigotes and 4 weeks after the inoculation, the animals were treated with different schemes, varying
from 1 to 3 doses. In all the experiments, Pentamidine Isethionate was used as reference drug under the same
experimental conditions. The results showed that one dose was not enough to heal the lesion, however, with 2 and
3 doses the efficiency of the assayed compound was clear. On the other hand, treatment with Pentamidine Isethionate
using the three different schemes was not satisfactory when compared to the curcuminoid derivative. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Diarylheptanoid | pt_BR |
Subject | Treatment trial | pt_BR |
Subject | Leishmania amazonensis | pt_BR |
Subject | Leishmaniasis | pt_BR |
e-ISSN | 1678-8060 | |