| Author | Carvalho, Leonardo J, de Moura | |
| Author | Alves, Francisco Acácio | |
| Author | Oliveira, Salma Gomes de | |
| Author | Valle, Rodrigo del Rio do | |
| Author | Fernandes, Andréa A. Morais | |
| Author | Muniz, José A. Pereira Carneiro | |
| Author | Daniel-Ribeiro, Claudio T. | |
| Access date | 2020-11-14T14:45:00Z | |
| Available date | 2020-11-14T14:45:00Z | |
| Document date | 2003 | |
| Citation | CARVALHO, Leonardo J. de Moura et al. Severe anemia affects both splenectomized and non-splenectomized Plasmodium falciparum-infected Aotus infulatus monkeys. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 5, p. 679-686, July 2003. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44411 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Malária | pt_BR |
| Subject in Portuguese | Plasmodium falciparum | pt_BR |
| Subject in Portuguese | Aotus infulatus | pt_BR |
| Subject in Portuguese | Modelo primata | pt_BR |
| Title | Severe anemia affects both splenectomized and non-splenectomized Plasmodium falciparum-infected Aotus infulatus monkeys | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02762003000500016 | |
| Abstract | Severe anemia is the earliest and a frequently fatal complication of Plasmodium falciparum infection. Here we
describe Aotus infulatus as a primate model suitable to study this malaria complication. Both non-splenectomized
and splenectomized monkeys receiving different inocula of P. falciparum FVO strain presented large (> 50%)
decreases in hematocrit values during infection. Non-splenectomized animals were able to control parasite growth
(parasitemia did not exceed 4%), but they had to be treated because of severe anemia. Three of 4 splenectomized
monkeys did not control parasitemia and were treated, but developed severe anemia after treatment when presenting
a negative blood film. Destruction of parasitized red blood cells alone cannot account for the degree of anemia.
Non-splenectomized monkeys repeatedly infected with homologous parasites became rapidly and progressively
resistant to reinfection and to the development of severe anemia. The data presented here point to A. infulatus as a
suitable model for studying the pathogenesis of severe malarial infection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia, WHO-collaborating Centre for Research and Training in Immunology of Parasitic Diseases. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Nacional de Primatas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Evandro Chagas. Funasa, Belém, PA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Nacional de Primatas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia, WHO-collaborating Centre for Research and Training in Immunology of Parasitic Diseases. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Nacional de Primatas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia, WHO-collaborating Centre for Research and Training in Immunology of Parasitic Diseases. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Plasmodium falciparum | pt_BR |
| Subject | Aotus infulatus | pt_BR |
| Subject | Primate model | pt_BR |
| e-ISSN | 1678-8060 | |
