| Author | Simonetti, S. R. R. | |
| Author | Schatzmayr, H. G. | |
| Author | Simonetti, J. P. | |
| Access date | 2020-11-14T15:43:24Z | |
| Available date | 2020-11-14T15:43:24Z | |
| Document date | 2003 | |
| Citation | SIMONETTI, S. R. R.; SCHATZMAYR, H. G.; SIMONETTI, J. P. Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n, 6, p. 831-837, Sept. 2003. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44417 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Vírus da imunodeficiência humana tipo 1 | pt_BR |
| Subject in Portuguese | Genotipagem | pt_BR |
| Subject in Portuguese | Resistência a medicamentos | pt_BR |
| Subject in Portuguese | Crianças brasileiras | pt_BR |
| Title | Human immunodeficiency virus type 1: drug resistance in treated and untreated brazilian children | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02762003000600021 | |
| Abstract | Twenty-two vertically human immunodeficiency virus type 1 (HIV-1) infected Brazilian children were studied for
antiretroviral drug resistance. They were separated into 2 groups according to the administration of antiretroviral
therapy into those who presented disease symptoms or without symptoms and no therapy. Viral genome sequencing
reactions were loaded on an automated DNA sampler (TruGene, Visible Genetics) and compared to a database of
wild type HIV-1. In the former group 8 of 12 children presented isolates with mutations conferring resistance to
protease inhibitors (PIs), 7 presented isolates resistant to nucleoside reverse transcriptase inhibitors (NRTIs) and
2 presented isolates resistant to non-nucleoside reverse transcriptase inhibitors (NNRTIs). Ten children were included
in the antiretroviral naïve group. Eight were susceptible to NRTIs and all of them were susceptible to PIs; one
presented the V108I mutation, which confers low-level resistance to NNRTIs. The data report HIV mutant isolates
both in treated and untreated infants. However, the frequency and the level of drug resistance were more frequent in
the group receiving antiretroviral therapy, corroborating the concept of selective pressure acting on the emergence
of resistant viral strains. The children who presented alterations at polymorphism sites should be monitored for the
development of additional mutations occurring at relevant resistance codons. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Núcleo de Retrovirus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Núcleo de Retrovirus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Núcleo de Retrovirus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Human immunodeficiency virus type 1 (HIV-1) | pt_BR |
| Subject | Genotyping | pt_BR |
| Subject | Drug resistance | pt_BR |
| Subject | Brazilian children | pt_BR |
| e-ISSN | 1678-8060 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
