| Author | Bandeira, Antonio Carlos | |
| Author | Gois, Luana Leandro | |
| Author | Campos, Gubio Soares | |
| Author | Sardi, Silvia | |
| Author | Yssel, Hans | |
| Author | Vieillard, Vincent | |
| Author | Autran, Brigitte | |
| Author | Grassi, Maria Fernanda Rios | |
| Access date | 2020-11-17T11:56:40Z | |
| Available date | 2020-11-17T11:56:40Z | |
| Document date | 2020 | |
| Citation | BANDEIRA, Antonio Carlos et al. Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic. The Brazilian Journal of Infectious Diseases, v. 24, n. 5, p. 405-411, 2020. | pt_BR |
| ISSN | 1413-8670 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44455 | |
| Sponsorship | Con-
selho Nacional de Desenvolvimento Cientifico e Tecnologico
(CNPq) and Fundacao Nacional de Desenvolvimento do Ensino
Superior Particular (FUNADESP). The authors are grateful to
Andris K. Walter for English language revision and copyediting
services. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Infectologia | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Vírus zika | pt_BR |
| Subject in Portuguese | Epidemia | pt_BR |
| Subject in Portuguese | Reação em cadeia da polimerase | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.bjid.2020.08.005 | |
| Abstract | Several major epidemics of Zika fever, caused by the ZIKA virus (ZIKV), have emerged in
Brazil since early 2015, eventually spreading to other countries on the South American con-
tinent. The present study describes the clinical manifestations and laboratory findings of
patients with confirmed acute ZIKV infection during the first epidemic that occurred in Sal-
vador, Brazil. All included patients were seen at the emergency room of a private tertiary
hospital located in Salvador, Brazil from 2015 through 2017. Patients were considered eligible
if signs of systemic viral febrile disease were present. All individuals were tested for ZIKV
and Chikungunya infection using PCR, while rapid test was used to detect Dengue virus anti-
bodies or, alternatively, the NS1 antigen. A diagnosis of acute ZIKV infection was confirmed
in 78/434 (18%) individuals with systemic viral febrile illness. Positivity was mainly observed
in blood, followed by saliva and urine. Coinfection with Chikungunya and/or Dengue virus
was detected in 5% of the ZIKV-infected patients. The most frequent clinical findings were
myalgia, arthralgia and low-grade fever. Laboratory analysis demonstrated normal levels
of hematocrit, platelets and liver enzymes. In summary, in acute settings where molecu-
lar testing remains unavailable, clinicians face difficulties to confirm the diagnosis of ZIKV
infection, as they rely only on clinical examinations and conventional laboratory tests | pt_BR |
| Affilliation | UniFTC. Faculdade de Medicina. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universite Pierre Marie-Curie. Sorbonne Universite. Centre d'Immunologie et des Maladies Infectieuses. Paris, France. | pt_BR |
| Affilliation | Universite Pierre Marie-Curie. Sorbonne Universite. Centre d'Immunologie et des Maladies Infectieuses. Paris, France. | pt_BR |
| Affilliation | Universite Pierre Marie-Curie. Sorbonne Universite. Centre d'Immunologie et des Maladies Infectieuses. Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | Clinical presentation | pt_BR |
| Subject | Polymerase chain reaction | pt_BR |
| Subject | Bahia | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
