Author | Carvalho, H. S. | |
Author | Baptista, M. L. | |
Author | Pinto, M. A. | |
Author | Silva, M. | |
Author | Takiya, C. M. | |
Author | Chagas, V. | |
Author | Pannain, V. | |
Author | Coelho, .H. S. M. | |
Author | Yoshida, C. F. T. | |
Access date | 2020-11-20T14:16:46Z | |
Available date | 2020-11-20T14:16:46Z | |
Document date | 2005 | |
Citation | CARVALHO, H. S. et al. Detection of hepatitis C virus RNA by in situ hybridization in paraformaldehyde fixed biopsies. memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 3, p. 269-272, May 2005. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/44555 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Hepatite viral | pt_BR |
Subject in Portuguese | Hibridização in situ | pt_BR |
Subject in Portuguese | Biópsia hepática | pt_BR |
Subject in Portuguese | Hepatite crônica | pt_BR |
Subject in Portuguese | Hepatitis C virus RNA | pt_BR |
Title | Detection of hepatitis C virus RNA by in situ hybridization in paraformaldehyde fixed biopsies | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/S0074-02762005000300009 | |
Abstract | Fourteen hepatitis C virus (HCV) chronically infected patients were submitted to routine liver biopsy for histological evaluation. Liver samples were assayed to HCV-RNA by in situ hybridization, using digoxigenin labeled
probe. HCV genotypes were found to be predominantly type 1 (71.4%), followed by genotype 3 (21.4%), and
genotype 2 (7.2%). Alanine-aminotransferase levels were raised in 10 patients. The histopathological scores were
minimal (21.4%), mild (57.2%), and moderate (21.4%). Viral RNA was detected in liver cells from nine patients
(64.3%). ISH method provides localization and poor confirmation of HCV RNA in the liver tissue of HCV chronic
patients. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Departamento de Histologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Clinica Médica, Setor de Gastroenterologia. Rio de Janeiro, RJ, Brasil. a | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Hepatitis C virus RNA | pt_BR |
Subject | In situ hybridization | pt_BR |
Subject | Liver biopsy | pt_BR |
Subject | Chronic hepatitis | pt_BR |
Subject | Viral hepatitis | pt_BR |
e-ISSN | 1678-8060 | |