| Author | Arruda, Mércia E. | |
| Author | Zimmerman, Robert H. | |
| Author | Souza, Renata M. C. | |
| Author | Ferreira, Joseli Oliveira | |
| Access date | 2020-11-22T18:58:47Z | |
| Available date | 2020-11-22T18:58:47Z | |
| Document date | 2007 | |
| Citation | ARRUDA, Mercia E. et al. Prevalence and level of antibodies to the circumsporozoite protein of human malaria parasites in five states of the Amazon region of Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 367-371, June 2007. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44575 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Plasmodium | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Subject in Portuguese | Região Amazônica | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Prevalence and level of antibodies to the circumsporozoite protein of human malaria parasites in five states of the Amazon region of Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02762007005000041 | |
| Abstract | The aim of this study was to determine the prevalence of malaria infection and antibodies against the repetitive epitopes of the circumsporozoite (CS) proteins of Plasmodium falciparum, P. malariae, P. vivax VK210, P.
vivax VK247, and P. vivax-like in individuals living in the states of Rondônia, Pará, Mato Grosso, Amazonas,
and Acre. Active malaria transmission was occurring in all studied sites, except in Acre. P. falciparum was the
predominant species in Pará and Rondônia and P. vivax in Mato Grosso. Infection by P. malariae was low but
this Plasmodium species was detected in Rondônia (3.5%), Mato Grosso (2.5%), and Pará (0.8%). High prevalence and levels of serological reactivity against the CS repeat peptides of P. falciparum were detected in Rondônia
(93%) and Pará (85%). Sera containing antibodies against the CS repeat of P. malariae occurred more frequently in Rondônia (79%), Pará (76%), and Amazonas (68%). Antibodies against the repeat epitope of the
standard CS protein of P. vivax VK210, P. vivax VK247, and P. vivax-like were more frequent in Rondônia, Pará,
and Mato Grosso. The high frequency of reactions to P. malariae in most of the areas suggests that the infection
by this Plasmodium species has been underestimated in Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | University of Florida. Florida Medical Entomology Laboratory. Gainesville. FL, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Plasmodium | pt_BR |
| Subject | Infection | pt_BR |
| Subject | Amazon region | pt_BR |
| Subject | Brazil | pt_BR |
| e-ISSN | 1678-8060 | |
