| Author | Bittar, Rita C. | |
| Author | Nogueira, Ricardo S. | |
| Author | Gonçalves, Ricardo Vieira | |
| Author | Ribeiro, Vanessa Pinho | |
| Author | Mattos, Marise S. | |
| Author | Oliveira Neto, Manoel Paes | |
| Author | Coutinho, Sergio G. | |
| Author | Cruz, Alda M. da | |
| Access date | 2020-11-22T19:58:36Z | |
| Available date | 2020-11-22T19:58:36Z | |
| Document date | 2007 | |
| Citation | BITTAR, Rita C. et al. T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 5, p. 625-630, Aug. 2007. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44579 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmania (Viannia) braziliensis | pt_BR |
| Subject in Portuguese | Infecção assintomática | pt_BR |
| Subject in Portuguese | Leishmaniose curada | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Subject in Portuguese | Subconjuntos de células T | pt_BR |
| Subject in Portuguese | Imunidade a longo prazo | pt_BR |
| Title | T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02762007005000069 | |
| Abstract | Subclinical or asymptomatic infection is documented in individuals living in endemic areas for leishmaniasis suggesting that the development of an appropriate immune response can control parasite replication and
maintain tissue integrity. A low morbidity indicates that intrinsic factors could favor resistance to Leishmania
infection. Herein, leishmanial T-cell responses induced in subjects with low susceptibility to leishmaniasis as
asymptomatic subjects were compared to those observed in cured cutaneous leishmaniasis (CCL) patients, who
controlled the disease after antimonial therapy. All of them have shown maintenance of specific long-term
immune responses characterized by expansion of higher proportions of CD4+ as compared to CD8+ Leishmania reactive T-lymphocytes. Asymptomatic subjects had lower indexes of in vitro Leishmania induced lymphoproliferative responses and interferon-gamma (IFN-γ) production in comparison to CCL patients. On the
other hand, interleukin (IL-10) production was much higher in asymptomatics than in CCL, while no differences
in IL-5 levels were found. In conclusion, long lived T-cell responses achieved by asymptomatic individuals
differed from those who had developed symptomatic leishmaniasis in terms of intensity of lymphocyte activation (proliferation or IFN-γ) and regulatory mechanisms (IL-10). The absence of the disease in asymptomatics
could be explained by their intrinsic ability to create a balance between immunoregulatory (IL-10) and effector
cytokines (IFN-γ), leading to parasite destruction without producing skin tissue damage. The establishment of profiles of cell-mediated immune responses associated with resistance against Leishmania infection is likely to
make new inroads into understanding the long-lived immune protection against the disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Asymptomatic infection | pt_BR |
| Subject | Leishmania (Viannia) braziliensis | pt_BR |
| Subject | Cured leishmaniasis | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | T-cell subsets | pt_BR |
| Subject | Long term immunity | pt_BR |
| e-ISSN | 1678-8060 | |
