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AutorVieira, Thiago de Souza
AutorIniguez, Eva
AutorCastro, Waldione de
AutorKarmakar, Subir
AutorDisotuar, Maria M.
AutorCecilio, Pedro
AutorLacsina, Joshua R.
AutorMeneses, Claudio
AutorNagata, Bianca M.
AutorCardoso, Silvia
AutorSonenshine, Daniel E.
AutorMoore, Ian N.
AutorBorges, Valeria de Matos
AutorDey, Ranadhir
AutorSoares, Miguel P.
AutorNakhasi, Hira L.
AutorOliveira, Fabiano
AutorValenzuela, Jesus G.
AutorKamhawi, Shaden
Fecha de acceso2020-11-23T14:15:33Z
Fecha de disponibilización2020-11-23T14:15:33Z
Fecha de publicación2020
ReferenciaVIEIRA, Thiago de Souza et al. Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance. Cell Reports, p. 1-18, Oct. 27 2020.pt_BR
ISSN2211-1247pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/44586
PromociónWe thank Ana Beatriz F. Barletta (LMVR, National Institute of Allergy and Infectious Diseases [NIAID]), Owen M. Schwartz, and Margery Smelkinson (Biological Imaging Facility, Research Technology Branch, NIAID) for their support with the confocal microscope and Lucas Tirloni (LMVR, NIAID) for his insights into tick biology. The graphical abstract is courtesy of Visual Medical Arts, NIAID, Rocky Mountain Labs; the illustration is by Ryan Kissinger. This research was supported by the Intramural Research Program of the NIH, NIAID. The findings of this study are an informal communication and representpt_BR
Idiomaengpt_BR
EditorCell Presspt_BR
Derechos de autoropen accesspt_BR
Palabras clave en PortuguésHeme oxigenasept_BR
Palabras clave en PortuguésInflamaçãopt_BR
Palabras clave en PortuguésPelept_BR
Palabras clave en PortuguésLeishmaniapt_BR
TítuloHeme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerancept_BR
Tipo del documentoArticlept_BR
DOI10.1016/j.celrep.2020.108317
Resumen en InglésHematophagous vectors lacerate host skin and capillaries to acquire a blood meal, resulting in leakage of red blood cells (RBCs) and inflammation. Here, we show that heme oxygenase-1 (HO-1), a pleiotropic cytoprotective isoenzyme that mitigates heme-mediated tissue damage, is induced after bites of sand flies, mosquitoes, and ticks. Further, we demonstrate that erythrophagocytosis by macrophages, including a skinresiding CD163+CD91+ professional iron-recycling subpopulation, produces HO-1 after bites. Importantly, we establish that global deletion or transient inhibition of HO-1 in mice increases inflammation and pathology following Leishmania-infected sand fly bites without affecting parasite number, whereas CO, an end product of the HO-1 enzymatic reaction, suppresses skin inflammation. This indicates that HO-1 induction by bloodfeeding sand flies promotes tolerance to Leishmania infection. Collectively, our data demonstrate that HO-1 induction through erythrophagocytosis is a universal mechanism that regulates skin inflammation following blood feeding by arthropods, thus promoting early-stage disease tolerance to vector-borne pathogens.pt_BR
AfiliaciónNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.pt_BR
AfiliaciónNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.pt_BR
AfiliaciónNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.pt_BR
AfiliaciónNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.pt_BR
AfiliaciónCenter for Biologics Evaluation and Research. Food and Drug Administration. Laboratory of Emerging Pathogens. Division of Emerging and Transfusion Transmitted Diseases. Silver Spring, MD, USApt_BR
AfiliaciónNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.pt_BR
AfiliaciónNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.pt_BR
AfiliaciónNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.pt_BR
AfiliaciónNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.pt_BR
AfiliaciónNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Infectious Disease Pathogenesis Section, Comparative Medicine Branch. Rockville, MD, USA.pt_BR
AfiliaciónInstituto Gulbenkian de Ciência. Oeiras, Lisboa, Portugal.pt_BR
AfiliaciónNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.pt_BR
AfiliaciónNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Infectious Disease Pathogenesis Section. Comparative Medicine Branch. Rockville, MD, USA.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.pt_BR
AfiliaciónCenter for Biologics Evaluation and Research. Food and Drug Administration. Laboratory of Emerging Pathogens. Division of Emerging and Transfusion Transmitted Diseases. Silver Spring, MD, USApt_BR
AfiliaciónInstituto Gulbenkian de Ciência. Oeiras, Lisboa, Portugal.pt_BR
AfiliaciónCenter for Biologics Evaluation and Research. Food and Drug Administration. Laboratory of Emerging Pathogens. Division of Emerging and Transfusion Transmitted Diseases. Silver Spring, MD, USApt_BR
AfiliaciónNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.pt_BR
AfiliaciónNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.pt_BR
Palavras clave en InglêsHeme oxigenaespt_BR
Palavras clave en InglêsInflammationpt_BR
Palavras clave en InglêsSkinpt_BR
Palavras clave en InglêsLeishmaniapt_BR


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