| Author | Sousa Jr., Ivanildo P. | |
| Author | Oliveira, Maria de Lourdes Aguiar | |
| Author | Burlandy, Fernanda M. | |
| Author | Machado, Raiana S. | |
| Author | Oliveira, Silas S. | |
| Author | Tavares, Fernando N. | |
| Author | Gomes Neto, Francisco | |
| Author | Costa, Eliane V. da | |
| Author | Silva, Edson E. da | |
| Access date | 2020-12-03T13:56:44Z | |
| Available date | 2020-12-03T13:56:44Z | |
| Document date | 2020 | |
| Citation | SOUSA JR., Ivanildo P. et al. Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brasil: a historical series (2005-2017). Emerging Microbes & Infections, v. 9, p. 2536-2546, Dec. 2020. | pt_BR |
| ISSN | 2222-1751 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44713 | |
| Language | eng | pt_BR |
| Publisher | Taylor & Francis | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Enterovírus não-poliomielite | pt_BR |
| Subject in Portuguese | Paralisia flácido aguda | pt_BR |
| Subject in Portuguese | Enterovirus | pt_BR |
| Subject in Portuguese | Epidemiologia molecular | pt_BR |
| Subject in Portuguese | Vigilância da poliomielite | pt_BR |
| Title | Molecular characterization and epidemiological aspects of non-polioenteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005-2017) | pt_BR |
| Type | Article | |
| DOI | 10.1080/22221751.2020.1850181 | |
| Abstract | Due to the advanced stage of polio eradication, the possible role of non-polio enteroviruses (NPEVs) associated to acute flaccid paralysis (AFP) cases has been highlighted. In this study, we described epidemiological aspects of NPEVs infections associated to AFP and explore the viral genetic diversity, information still scarce in Brazil. From 2005 to 2017, 6707 stool samples were collected in the scope of the Brazilian Poliomyelitis Surveillance Program. NPEVs were isolated in 359 samples (5.3%) and 341 (94.9%) were genotyped. About 46 different NPEV types were identified with the following detection pattern EV-B > EV-A > EV-C. The major EV-types were CVA2, CV4, EV-A71, CVB3, CVB5, E6, E7, E11, CVA13 and EV-C99, which corresponds to 51.6% of the total. Uncommon types, such as CVA12, EV-90 and CVA11, were also identified. Different E6 genogroups were observed, prevailing the GenIII, despite periods of co-circulation, and replacement of genogroups along time. CVA2 sequences were classified as genotype C and data suggested its dispersion in South-American countries. CVA13 viruses belonged to cluster B and Venezuelan viruses composed a new putative cluster. This study provides extensive information on enterovirus diversity associated with AFP, reinforcing the need of tailoring current surveillance strategies to timely monitor emergence/re-emergence of NPEVs. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Evandro Chagas. Seção de Virologia. Laboratório de Referência Regional em Enteroviroses. Ananindeua, PA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Non-polio enterovirus | pt_BR |
| Subject | Acute flaccid paralysis | pt_BR |
| Subject | Enterovirus | pt_BR |
| Subject | Molecular epidemiology | pt_BR |
| Subject | Poliomyelitis surveillance | pt_BR |
