| Author | Nielebock, Marco Antonio Prates | |
| Author | Moreira, Otacilio Cruz | |
| Author | Xavier, Samanta Cristina das Chagas | |
| Author | Miranda, Luciana de Freitas Campos | |
| Author | Lima, Ana Carolina Bastos de | |
| Author | Pereira, Thayanne Oliveira de Jesus Sales | |
| Author | Hasslocher-Moreno, Alejandro Marcel | |
| Author | Britto, Constança | |
| Author | Sangenis, Luiz Henrique Conde | |
| Author | Saraiva, Roberto Magalhães | |
| Access date | 2020-12-09T14:56:45Z | |
| Available date | 2020-12-09T14:56:45Z | |
| Document date | 2020 | |
| Citation | NIELEBOCK, Marco Antonio Prates et al. Association between Trypanosoma cruzi DTU TcII and chronic Chagas disease clinical presentation and outcome in an urban cohort in Brazil. Plos One, v. 15, n. 2, e0243008, p. 1-15, Dec. 2020. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44756 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Doença de Chagas Crônica | pt_BR |
| Subject in Portuguese | Coorte urbano | pt_BR |
| Subject in Portuguese | Apresentação clínica | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi DTU TcII | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Association between Trypanosoma cruzi DTU TcII and chronic Chagas Disease clinical presentation and outcome in an urban cohort in Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0243008 | |
| Abstract | Background: The specific roles of parasite characteristics and immunological factors of the host in Chagas disease progression and prognosis are still under debate. Trypanosoma cruzi genotype may be an important determinant of the clinical chronic Chagas disease form and prognosis. This study aimed to identify the potential association between T. cruzi genotypes and the clinical presentations of chronic Chagas disease. Methodology/principal findings: This is a retrospective study using T. cruzi isolated from blood culture samples of 43 patients with chronic Chagas disease. From 43 patients, 42 were born in Brazil, mainly in Southeast and Northeast Brazilian regions, and one patient was born in Bolivia. Their mean age at the time of blood collection was 52.4±13.2 years. The clinical presentation was as follows 51.1% cardiac form, 25.6% indeterminate form, and 23.3% cardiodigestive form. Discrete typing unit (DTU) was determined by multilocus conventional PCR. TcII (n = 40) and TcVI (n = 2) were the DTUs identified. DTU was unidentifiable in one patient. The average follow-up time after blood culture was 5.7±4.4 years. A total of 14 patients (32.5%) died and one patient underwent heart transplantation. The cause of death was sudden cardiac arrest in six patients, heart failure in five patients, not related to Chagas disease in one patient, and ignored in two patients. A total of 8 patients (18.6%) progressed, all of them within the cardiac or cardiodigestive forms. Conclusions/significance: TcII was the main T. cruzi DTU identified in chronic Chagas disease Brazilian patients (92.9%) with either cardiac, indeterminate or cardiodigestive forms, born at Southeast and Northeast regions. Other DTU found in much less frequency was TcVI (4.8%). TcII was also associated to patients that evolved with heart failure or sudden cardiac arrest, the two most common and ominous consequences of the cardiac form of Chagas disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infeciosas Evandro Chagas. Laboratório de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infeciosas Evandro Chagas. Laboratório de Vigilãncia de Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infeciosas Evandro Chagas. Laboratório de Pesquisa Clínicca em Doenças de Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infeciosas Evandro Chagas. Laboratório de Pesquisa Clínicca em Doenças de Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infeciosas Evandro Chagas. Laboratório de Pesquisa Clínicca em Doenças de Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infeciosas Evandro Chagas. Laboratório de Pesquisa Clínicca em Doenças de Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Trypanosoma cruzi DTU TcII | pt_BR |
| Subject | Chronic Chagas Disease | pt_BR |
| Subject | Urban cohort | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Clinical presentation | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 11 Cidades e comunidades sustentáveis | |
