| Author | Bosch, Marta | |
| Author | Sánchez-Álvarez, Miguel | |
| Author | Fajardo, Alba | |
| Author | Kapenatovic, Ronan | |
| Author | Steiner, Bernhard | |
| Author | Dutra, Filipe | |
| Author | Moreira, Luciana | |
| Author | López, Juan Antonio | |
| Author | Campo, Rocio | |
| Author | Mari, Montserrat | |
| Author | Morales-Paytuví, Frederic | |
| Author | Tort, Olivia | |
| Author | Gubern, Albert | |
| Author | Templin, Rachel M. | |
| Author | Curson, James E. B. | |
| Author | Martel, Nick | |
| Author | Catelá, Cristina | |
| Author | Lozano, Francisco | |
| Author | Tebar, Fransesc | |
| Author | Martel, Carlos | |
| Author | Vásquez, Jésus | |
| Author | Del Pozo, Miguel A. | |
| Author | Sweet, Mathew J. | |
| Author | Bozza, Patrícia T. | |
| Author | Gross, Steven P. | |
| Author | Parton, Robert G. | |
| Author | Pol, Albert | |
| Access date | 2020-12-10T19:09:29Z | |
| Available date | 2020-12-10T19:09:29Z | |
| Document date | 2020 | |
| Citation | BOSCH, Marta et al. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Science, v. 370, n. 6514, easy 8085, 14p, Oct. 2020. | pt_BR |
| ISSN | 1662-811X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44797 | |
| Language | eng | pt_BR |
| Publisher | Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Gotículas lipídicas | pt_BR |
| Subject in Portuguese | Lipídios de mamíferos | pt_BR |
| Subject in Portuguese | Centros imunes inatos | pt_BR |
| Subject in Portuguese | Metabolismo celular | pt_BR |
| Subject in Portuguese | Defesa do hospedeiro | pt_BR |
| Title | Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense | pt_BR |
| Type | Article | |
| DOI | 10.1126/science.aay8085 | |
| Abstract | Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD-bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection. | pt_BR |
| Affilliation | Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036. Barcelona, Spain / Department of Biomedical Sciences, Faculty of Medicine, Universitat de Barcelona. 08036, Barcelona, Spain. | pt_BR |
| Affilliation | Mechanoadaptation and Caveolae Biology Laboratory, Cell and Developmental Biology Area. Centro Nacional de Investigaciones Cardiovasculares (CNIC). 28029, Madrid, Spain. | pt_BR |
| Affilliation | Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036. Barcelona, Spain. | pt_BR |
| Affilliation | Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia / MB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, Queensland 4072, Australia / Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland 4072, Australia. | pt_BR |
| Affilliation | Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.. | pt_BR |
| Affilliation | Cardiovascular Proteomics Laboratory, Vascular Pathophysiology Area, CNIC, Instituto de Salud Carlos III 28029, Madrid, Spain / Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares (CIBER-CV), Instituto de Salud Carlos III 28029, Madrid, Spain. | pt_BR |
| Affilliation | Cardiovascular Proteomics Laboratory, Vascular Pathophysiology Area, CNIC, Instituto de Salud Carlos III 28029, Madrid, Spain. | pt_BR |
| Affilliation | Department of Cell Death and Proliferation, Institut d'Investigacions Biomèdiques de Barcelona (IIBB)–CSIC, Barcelona, Spain / Hepatocellular Signaling and Cancer Team, IDIBAPS, 08036, Barcelona, Spain. | pt_BR |
| Affilliation | Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain. | pt_BR |
| Affilliation | Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain. | pt_BR |
| Affilliation | Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain. | pt_BR |
| Affilliation | Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia / Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4072, Australia. | pt_BR |
| Affilliation | Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia / IMB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, Queensland 4072, Australia / Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland 4072, Australia.. | pt_BR |
| Affilliation | Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia. | pt_BR |
| Affilliation | Immunoreceptors of the Innate and Adaptive System Team, IDIBAPS, 08036, Barcelona, Spain. | pt_BR |
| Affilliation | Immunoreceptors of the Innate and Adaptive System Team, IDIBAPS, 08036, Barcelona, Spain. | pt_BR |
| Affilliation | Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036. Barcelona, Spain / Department of Biomedical Sciences, Faculty of Medicine, Universitat de Barcelona. 08036, Barcelona, Spain. | pt_BR |
| Affilliation | Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036. Barcelona, Spain / Department of Biomedical Sciences, Faculty of Medicine, Universitat de Barcelona. 08036, Barcelona, Spain. | pt_BR |
| Affilliation | Cardiovascular Proteomics Laboratory, Vascular Pathophysiology Area, CNIC, Instituto de Salud Carlos III 28029, Madrid, Spain / Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares (CIBER-CV), Instituto de Salud Carlos III 28029, Madrid, Spain. | pt_BR |
| Affilliation | Mechanoadaptation and Caveolae Biology Laboratory, Cell and Developmental Biology Area. Centro Nacional de Investigaciones Cardiovasculares (CNIC). 28029, Madrid, Spain. | pt_BR |
| Affilliation | Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia / MB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, Queensland 4072, Australia / Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland 4072, Australia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.. | pt_BR |
| Affilliation | Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA. | pt_BR |
| Affilliation | Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia / Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4072, Australia. | pt_BR |
| Affilliation | Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036. Barcelona, Spain / Department of Biomedical Sciences, Faculty of Medicine, Universitat de Barcelona. 08036, Barcelona, Spain / Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010, Barcelona.. | pt_BR |
| Subject | Mammalian lipid droplets | pt_BR |
| Subject | Innate immune hubs | pt_BR |
| Subject | Cell metabolism | pt_BR |
| Subject | Host defense | pt_BR |
| e-ISSN | 1662-8128 | |
