| Author | Souza-Souza, Kauê F. C. | |
| Author | Albuquerque, Cassiano F. Gonçalves de | |
| Author | Santos, Cláudio Cirne | |
| Author | Paixão, Isabel C. N. P. | |
| Author | Buth, Patrícia | |
| Access date | 2020-12-10T19:27:57Z | |
| Available date | 2020-12-10T19:27:57Z | |
| Document date | 2020 | |
| Citation | SOUZA-SOUZA, Kauê F. C. et al. Alphavirus Replication: The Role of Cardiac Glycosides and Ion Concentration in Host Cells. BioMed Research International, Vol. 2020, ID 2813253, 7p, 2020. | pt_BR |
| ISSN | 2314-6133 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44798 | |
| Language | eng | pt_BR |
| Publisher | Hindawi | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Replicação de alfavírus | pt_BR |
| Subject in Portuguese | Glicosídeos cardíacos | pt_BR |
| Subject in Portuguese | Concentração de íons | pt_BR |
| Subject in Portuguese | Células hospedeiras | pt_BR |
| Title | Alphavirus Replication: The Role of Cardiac Glycosides and Ion Concentration in Host Cells | pt_BR |
| Type | Article | |
| DOI | 10.1155/2020/2813253 | |
| Abstract | Alphaviruses are arthropod-borne viruses that can cause fever, rash, arthralgias, and encephalitis. The mosquito species Aedes aegypti and Aedes albopictus are the most frequent transmitters of alphaviruses. There are no effective vaccines or specific antivirals available for the treatment of alphavirus-related infections. Interestingly, changes in ion concentration in host cells have been characterized as critical regulators of the alphavirus life cycle, including fusion with the host cell, glycoprotein trafficking, genome translation, and viral budding. Cardiac glycosides, which are classical inhibitors of the Na+ K+ ATPase (NKA), can inhibit alphavirus replication although their mechanisms of action are poorly understood. Nonetheless, results from multiple studies suggest that inhibition of NKA may be a suitable strategy for the development of alphavirus-specific antiviral treatments. This review is aimed at exploring the role of changes in ion concentration during alphavirus replication and at considering the possibility of NKA as a potential therapeutic target for antiviral drugs. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil. | pt_BR |
| Subject | Alphavirus Replication | pt_BR |
| Subject | Cardiac Glycosides | pt_BR |
| Subject | Ion Concentration | pt_BR |
| Subject | Host Cells | pt_BR |
| e-ISSN | 2314-6141 | |
