| Author | Silva, L. B. | |
| Author | Bock, D. | |
| Author | Klafke, G. B. | |
| Author | Sanchotene, K. O. | |
| Author | Basso, R. P. | |
| Author | Benelli, J. L. | |
| Author | Poester, V. R. | |
| Author | Silva, F. A. | |
| Author | Trilles, L. | |
| Author | Severo, C. B. | |
| Author | Stevens, D. A. | |
| Author | Xavier, M. O. | |
| Access date | 2020-12-15T13:52:14Z | |
| Available date | 2020-12-15T13:52:14Z | |
| Document date | 2020 | |
| Citation | SILVA, L. B. et al. Cryptococcosis in HIV-AIDS patients from Southern Brazil: Still a major problem. Journal de Mycologie Me´dicale, p. 1-5, 2020. | pt_BR |
| ISSN | 1156-5233 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44889 | |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Cryptococcosis in HIV-AIDS patients from Southern Brazil: Still a major problem | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.mycmed.2020.101044 | pt_BR |
| Abstract | Introduction: Cryptococcus neoformans is an opportunistic pathogen that causes 15% mortality in AIDS patients. Rio Grande City, Rio Grande do Sul (RS), Brazil, has the highest national rate of HIV/AIDS, considering cities with population more than 100,000 habitants. Objective: We aimed to evaluate the clinical and epidemiological profile of cryptococcosis in a reference service for HIV-AIDS patients in the South region of Brazil, over seven years. Material and methods A retrospective study was performed including all cryptococcosis cases diagnosed at the University Hospital, Federal University of Rio Grande (UH-FURG) between January 2010 and December 2016. Results: Seventy cases of cryptococcosis were diagnosis from 2010 to 2016 in the UH-FURG in the seven years of the study. These numbers were responsible for 2.1% to 8.1% of the hospitalizations/year for HIV patients. All were caused by C. neoformans infection (95% C. neoformans var. grubii VNI and 5% C. neoformans var. grubii VNII). Neurocryptococcosis was the major clinical manifestation and cryptococcosis was the HIV- defining condition in 40% of patients. The period of hospitalization was an average of 39.3 days (SD = 31.3), and more than half of patients (53%; 37/70) died after a mean of 82 days. Discussion: The present study showed the importance of cryptococcosis as an AIDS-defining disease in HIV-AIDS patients in a tertiary hospital from Southern Brazil. More investment is necessary to reduce the impact of this opportunistic mycosis in HIV-AIDS patients from southern Brazil. | pt_BR |
| Affilliation | Federal University of Rio Grande. Mycology Laboratory of Faculty of Medicine. Porto Alegre, RS, Brazil / Federal University of Rio Grande. Faculty of Medicine. Program Post-Graduation in Health Sciences. Rio Grande, RS, Brazil. | pt_BR |
| Affilliation | Federal University of Rio Grande. Mycology Laboratory of Faculty of Medicine. Porto Alegre, RS, Brazil. | pt_BR |
| Affilliation | Federal University of Rio Grande. Mycology Laboratory of Faculty of Medicine. Porto Alegre, RS, Brazil / Federal University of Rio Grande. Faculty of Medicine. Program Post-Graduation in Health Sciences. Rio Grande, RS, Brazil. | pt_BR |
| Affilliation | Federal University of Rio Grande. Faculty of Medicine. Program Post-Graduation in Health Sciences. Rio Grande, RS, Brazil. | pt_BR |
| Affilliation | Federal University of Rio Grande. Faculty of Medicine. Program Post-Graduation in Health Sciences. Rio Grande, RS, Brazil. | pt_BR |
| Affilliation | Federal University of Rio Grande. Mycology Laboratory of Faculty of Medicine. Porto Alegre, RS, Brazil / Federal University of Rio Grande. Faculty of Medicine. Program Post-Graduation in Health Sciences. Rio Grande, RS, Brazil. | pt_BR |
| Affilliation | Foundation Oswaldo Cruz. National Institute of Infectology. Mycology Laboratory. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Foundation Oswaldo Cruz. National Institute of Infectology. Mycology Laboratory. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Federal University of Health Sciences of Porto Alegre. Porto Alegre, RS, Brazil. | pt_BR |
| Affilliation | California Institute for Medical Research. San Jose, California, USA / Stanford University Medical School. Division of Infectious Diseases and Geographic Medicine. Stanford, California, USA. | pt_BR |
| Affilliation | Federal University of Rio Grande. Mycology Laboratory of Faculty of Medicine. Porto Alegre, RS, Brazil / Program Post-Graduation in Health Sciences. Porto Alegre, RS, Brazil. | pt_BR |
| Subject | Cryptococcus neoformans | pt_BR |
| Subject | Cryptococcosis | pt_BR |
| Subject | Epidemiology | pt_BR |
| Subject | HIV-AIDS | pt_BR |
| Subject | Opportunistic infections | pt_BR |
| Subject | Fungal meningitis | pt_BR |
