| Author | Calvo, Thyago Leal | |
| Author | Moraes, Milton Ozório | |
| Access date | 2020-12-21T20:16:21Z | |
| Available date | 2020-12-21T20:16:21Z | |
| Document date | 2019 | |
| Citation | CALVO, Thiago Leal; MORAES, Milton Ozório. Reanalysis and integration of public microarray datasets reveals novel host genes modulated in Leprosy. bioRxiv, p. 1-23, 2019. | |
| ISSN | 1617-4615 | |
| URI | https://www.arca.fiocruz.br/handle/icict/45064 | |
| Language | eng | en_US |
| Publisher | Springer | |
| Rights | open access | |
| Subject in Portuguese | Reanálise | pt_BR |
| Subject in Portuguese | Dados públicos | pt_BR |
| Subject in Portuguese | Microarray | pt_BR |
| Subject in Portuguese | Novos genes hospedeiros | pt_BR |
| Subject in Portuguese | Hanseníase | pt_BR |
| Title | Reanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosy | en_US |
| Type | Preprint | |
| DOI | 10.1101/824805 | |
| Abstract | Leprosy is an insidious disease caused primarily by mycobacteria. The difficulties in culturing this slow-growing bacteria together with the chronic progression of the disease have hampered the development of accurate methods for diagnosis. Host gene expression profiling is an important tool to assess overall tissue activity, whether in health or disease conditions. High-throughput gene expression experiments have become popular over the last decade or so, and public databases have been created to easily store and retrieve these data. This has enabled researchers to reuse and reanalyze existing datasets with the aim of generating novel and or more robust information. In this work, after a systematic search, nine microarray datasets evaluating host gene expression in leprosy were reanalyzed and the information was integrated to strengthen evidence of differential expression for several genes. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Subject | Leprosy | en_US |
| Subject | Reanalysis | en_US |
| Subject | Public Datasets | en_US |
| Subject | Microarray | en_US |
| Subject | Novel Host Genes | en_US |
| e-ISSN | 1617-4623 | |
