| Autor | Sabioni, Letícia | |
| Autor | Lorenzo, Andrea De | |
| Autor | Lamas, Cristiane | |
| Autor | Muccillo, Fabiana | |
| Autor | Faria Neto, Hugo Caire C. | |
| Autor | Estato, Vanessa | |
| Autor | Tibiriça, Eduardo | |
| Data de acesso | 2020-12-29T14:33:47Z | |
| Data de disponibilização | 2020-12-29T14:33:47Z | |
| Data do publicação | 2020 | |
| Citação | SABIONI, Letícia et al. Systemic microvascular endothelial dysfunction and disease severity in COVID-19 patients: Evaluation by laser Doppler perfusion monitoring and cytokine/chemokine analysis. Microvascular Research, v. 134, 104119, p. 1-10, Dec. 2020. | pt_BR |
| ISSN | 0026-2862 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/45463 | |
| Descrição | Cristiane Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. | pt_BR |
| Descrição | Disponível on line em dezembro de 2020. Open Access pathways permitted by this journal's policy are listed below by article version. Click on a pathway for a more detailed view.Published Version [pathway b] - No Embargo Institutional Repository, Subject Repository, PMC, Research for Development Repository. | pt_BR |
| Descrição | Since January 2020 Elsevier has created a COVID-19 resource centre with
free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the
company's public news and information website.
Elsevier hereby grants permission to make all its COVID-19-related
research that is available on the COVID-19 resource centre - including this
research content - immediately available in PubMed Central and other
publicly funded repositories, such as the WHO COVID database with rights
for unrestricted research re-use and analyses in any form or by any means
with acknowledgement of the original source. These permissions are
granted for free by Elsevier for as long as the COVID-19 resource centre
remains active. | pt_BR |
| Idioma | eng | pt_BR |
| Editor | Elsevier | pt_BR |
| Direito Autoral | open access | |
| Palavras-chave | COVID-19 | pt_BR |
| Palavras-chave | Disfunção endotelial microvascular sistêmica | pt_BR |
| Palavras-chave | Pacientes | pt_BR |
| Palavras-chave | Monitoramento | pt_BR |
| Palavras-chave | Perfusão por laser Doppler | pt_BR |
| Palavras-chave | Análise de citocinas / quimiocinas | pt_BR |
| Título | Systematic microvascular endothelial dysfunction and disease severity in COVID-19 patients: Evaluation by laser Doppler perfusion monitoring and cytokine/chemokine analysis | pt_BR |
| Tipo do documento | Article | |
| DOI | 10.1016/j.mvr.2020.104119 | |
| Resumo em Inglês | Background: Microvascular dysfunction, serum cytokines and chemokines may play important roles in pathophysiology of coronavirus disease 2019 (COVID-19), especially in severe cases. Methods: Patients with COVID-19 underwent non-invasive evaluation of systemic endothelium-dependent microvascular reactivity - using laser Doppler perfusion monitoring in the skin of the forearm - coupled to local thermal hyperemia. Maximal microvascular vasodilatation (44 °C thermal plateau phase) was used as endpoint. A multiplex biometric immunoassay was used to assess a panel of 48 serum cytokines and chemokines. Severe COVID-19 (S-COVID) was defined according to WHO criteria, while all other cases of COVID-19 were considered mild to moderate (M-COVID). A group of healthy individuals who tested negative for SARS-CoV-2 served as a control group and was also evaluated with LDPM. Results: Thirty-two patients with COVID-19 (25% S-COVID) and 14 controls were included. Basal microvascular flow was similar between M-COVID and controls (P = 0.69) but was higher in S-COVID than in controls (P = 0.005) and M-COVID patients (P = 0.01). The peak microvascular vasodilator response was markedly decreased in both patient groups (M-COVID, P = 0.001; S-COVID, P < 0.0001) compared to the healthy group. The percent increases in microvascular flow were markedly reduced in both patient groups (M-COVID, P < 0.0001; S-COVID, P < 0.0001) compared to controls. Patients with S-COVID had markedly higher concentrations of dissimilar proinflammatory cytokines and chemokines, compared to patients with M-COVID. Conclusions: In patients with COVID-19, especially with S-COVID, endothelium-dependent microvascular vasodilator responses are reduced, while serum cytokines and chemokines involved in the regulation of vascular function and inflammation are increased. | pt_BR |
| Afiliação | Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Palavras-chave em inglês | COVID-19 | pt_BR |
| Palavras-chave em inglês | Laser Doppler perfusion monitoring | pt_BR |
| Palavras-chave em inglês | Patients | pt_BR |
| Palavras-chave em inglês | Laser Doppler perfusion monitoring | pt_BR |
| Palavras-chave em inglês | Endothelial dysfunction | pt_BR |
| Palavras-chave em inglês | Proinflammatory cytokine | pt_BR |
