Author | Vinhaes, Caian Leal | |
Author | Teixeira, Rozana S. | |
Author | Monteiro Júnior, Jay A. S. | |
Author | Tibúrcio, Rafael | |
Author | Cubillos-Angulo, Juan Manuel | |
Author | Arriaga Gutiérrez, María Belen | |
Author | Sabarin, Adrielle G. | |
Author | Souza, Amâncio J. de | |
Author | Silva, Jacqueline J. | |
Author | Lyra, Isa M. | |
Author | Ladeia, Ana Marice Teixeira | |
Author | Andrade, Bruno de Bezerril | |
Access date | 2021-01-04T18:17:57Z | |
Available date | 2021-01-04T18:17:57Z | |
Document date | 2020 | |
Citation | VINHAES, Caian Leal et al. treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia. Scientific Reports, v. 10, p. 1-10, 2020. | pt_BR |
ISSN | 2045-2322 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/45499 | |
Sponsorship | Hematology and Hemotherapy Foundation
of Bahia (HEMOBA) for the critical assistance in patient recruitment and evaluation. This work was supported by
the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) under the notice number 020/201—Research
Program: shared health management—(PPSUS) of Bahia (Award Number: EFP00006943). The funders had no
role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The work
of Bruno B. Andrade is supported by the Intramural Research Program of the Fundação Oswaldo Cruz. Bruno
B. Andrade is a senior research fellow from the Conselho Nacional de Desenvolvimento Científico e Tecnológico
(CNPq). Caian L. Vinhaes received a research fellowship from the CNPq. Juan M. Cubillos-Angulo received a
PhD fellowship from the Organization of American States—Partnerships Program for Education and Training
(OAS-PAEC) and the Coordenação de Aperfeiçoamento de pessoal de Nível Superior Brasil (CAPES, Finance
Code 001). Rafael Tibúrcio received a PhD fellowships from CAPES and María B. Arriaga received a PhD from
the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). | pt_BR |
Language | eng | pt_BR |
Publisher | Nature Research | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Hidroxiureia | pt_BR |
Subject in Portuguese | Anemia falciforme | pt_BR |
Subject in Portuguese | Crianças | pt_BR |
Subject in Portuguese | Adolescentes | pt_BR |
Subject in Portuguese | Tratamento | pt_BR |
Title | Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/s41598-020-76075-5 | |
Abstract | Sickle cell anemia (SCA) is the most common inherited hemolytic anemia worldwide. Here, we performed an exploratory study to investigate the systemic oxidative stress in children and adolescents with SCA. Additionally, we evaluated the potential impact of hydroxyurea therapy on the status of oxidative stress in a case–control study from Brazil. To do so, a panel containing 9 oxidative stress markers was measured in plasma samples from a cohort of 47 SCA cases and 40 healthy children and adolescents. Among the SCA patients, 42.5% were undertaking hydroxyurea. Multidimensional analysis was employed to describe disease phenotypes. Our results demonstrated that SCA is associated with increased levels of oxidative stress markers, suggesting the existence of an unbalanced inflammatory response in peripheral blood. Subsequent analyses revealed that hydroxyurea therapy was associated with diminished oxidative imbalance in SCA patients. Our findings reinforce the idea that SCA is associated with a substantial dysregulation of oxidative responses which may be dampened by treatment with hydroxyurea. If validated by larger prospective studies, our observations argue that reduction of oxidative stress may be a main mechanism through which hydroxyurea therapy attenuates the tissue damage and can contribute to improved clinical outcomes in SCA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. School of Medicine. Salvador, BA, Brasil / | pt_BR |
Affilliation | Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil / Federal University of Bahia. School of Medicine. Salvador, BA, Brazil. | pt_BR |
Affilliation | Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Federal University of Bahia. School of Medicine. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Federal University of Bahia. School of Medicine. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Federal University of Bahia. School of Medicine. Salvador, BA, Brazil. | pt_BR |
Affilliation | Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil. | pt_BR |
Affilliation | Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil. | pt_BR |
Affilliation | University Salvador. Laureate International Universities. Salvador, BA, Brazil. | pt_BR |
Affilliation | Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil / Catholic University of Salvador. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. School of Medicine. Salvador, BA, Brasil / Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil / Federal University of Bahia. School of Medicine. Salvador, BA, Brazil / University Salvador. Laureate International Universities, Salvador, BA, Brazil. | pt_BR |
Subject | Hydroxyurea | pt_BR |
Subject | Anemia Sickle Cell | pt_BR |
Subject | Children | pt_BR |
Subject | Adolescents | pt_BR |
Subject | Treatment | pt_BR |