| Author | França, Guilherme de Oliveira | |
| Author | Frantz, Eliete Dalla Corte | |
| Author | Magliano, D'Angelo Carlo | |
| Author | Bargut, Thereza Cristina Lonzetti | |
| Author | Sepúlveda-Fragoso, Vinicius | |
| Author | Silvares, Raquel Rangel | |
| Author | Daliry, Anissa | |
| Author | Nascimento, Alessandro Rodrigues do | |
| Author | Borges, Juliana Pereira | |
| Access date | 2021-01-06T18:55:40Z | |
| Available date | 2021-01-06T18:55:40Z | |
| Document date | 2020 | |
| Citation | FRANÇA, Guilherme de Oliveira et al. Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats. Life Sciences, n. 256, 117920, 9p, June 2020. | pt_BR |
| ISSN | 0024-3205 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/45516 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Cardioproteção | pt_BR |
| Subject in Portuguese | Obesidade | pt_BR |
| Subject in Portuguese | Obesidade sarcopenica | pt_BR |
| Subject in Portuguese | Composição corporal | pt_BR |
| Subject in Portuguese | Treinamento intervalado de alta intensidade | pt_BR |
| Title | Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.lfs.2020.117920 | |
| Abstract | Aim: We investigated the effects of high-intensity interval and continuous short-term exercise on body composition
and cardiac function after myocardial ischemia-reperfusion injury (IRI) in obese rats.
Methods: Rats fed with a standard chow diet (SC) or high-fat diet (HFD) for 20 weeks underwent systolic blood
pressure (SBP), glycemia and dual-energy X-ray absorptiometry analyses. Then, animals fed with HFD were
subdivided into three groups: sedentary (HFD-SED); moderate-intensity continuous training (HFD-MICT); and
high-intensity interval training (HFD-HIIT). Exercised groups underwent four isocaloric aerobic exercise sessions,
in which HFD-MICT maintained the intensity continuously and HFD-HIIT alternated it. After exercise
sessions, all groups underwent global IRI and myocardial infarct size (IS) was determined histologically. Fat and
muscle mass were weighted, and protein levels involved in muscle metabolism were assessed in skeletal muscle.
Results: HFD-fed versus SC-fed rats reduced lean body mass by 31% (P < 0.001), while SBP, glycemia and body
fat percentage were increased by 10% (P=0.04), 30% (P=0.006) and 54% (P < 0.001); respectively. HFDinduced
muscle atrophy was restored in exercised groups, as only HFD-SED presented lower gastrocnemius
(32%; P=0.001) and quadriceps mass (62%; P < 0.001) than SC. PGC1-α expression was 2.7-fold higher in
HFD-HIIT versus HFD-SED (P=0.04), whereas HFD-HIIT and HFD-MICT exhibited 1.7-fold increase in pmTORSer2481
levels compared to HFD-SED (P=0.04). Although no difference was detected among groups for IS
(P=0.30), only HFD-HIIT preserved left-ventricle developed pressure after IRI (+0.7 mmHg; P=0.9).
Significance: Short-term exercise, continuous or HIIT, restored HFD-induced muscle atrophy and increased
mTOR expression, but only HIIT maintained myocardial contractility following IRI in obese animals. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Educação Física e Esportes. Laboratorio de Atividade Física e Promoção da Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Departamento de Morfologia. Laboratório de Análises Morfológicas e Metabólicas. Niterói, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia. (In)activity and Exercise. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto Biomédico.Departamento de Morfologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Departamento de Morfologia. Laboratório de Análises Morfológicas e Metabólicas. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Saude de Nova Friburgo. Departamento de Ciências Bàsicas. Nova Friburgo, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Departamento de Morfologia. Laboratório de Análises Morfológicas e Metabólicas. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Educação Física e Esportes. Laboratorio de Atividade Física e Promoção da Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Langendorff | pt_BR |
| Subject | Cardioprotection | pt_BR |
| Subject | Obesity | pt_BR |
| Subject | Sarcopenic obesity | pt_BR |
| Subject | High-intensity interval training | pt_BR |
| Subject | Body composition | pt_BR |
