| Author | Pedrosa, Carolina da S. G. | |
| Author | Souza, Leticia R. Q; | |
| Author | Gomes, Tiago A. | |
| Author | Lima, Caroline V. F. de | |
| Author | Ledur, Pitia F. | |
| Author | Karmirian, Karina | |
| Author | Barbeito-Andres, JImena | |
| Author | Costa, Marcelo do N. | |
| Author | Higa, Luiza M. | |
| Author | Rossi, Átila D. | |
| Author | Bello, Maria | |
| Author | Tanuri, Amilcar | |
| Author | Barbosa, Arnaldo Prata | |
| Author | Tovar-Moll, Fernanda | |
| Author | Garcez, Patricia P. | |
| Author | Lara, Flavio A. | |
| Author | Molica, Renato J. R. | |
| Author | Rehen, Stevens K. | |
| Access date | 2021-01-06T20:12:12Z | |
| Available date | 2021-01-06T20:12:12Z | |
| Document date | 2020 | |
| Citation | PEDROSA, Carolina da S. G. et al. The cyanobacterial saxitoxin exacerbates neural cell death and brain malformations induced by Zika virus. Plos Negl. Trop. Dis., v. 14, n. 3, 0008060, 13p, Mar. 2020. | pt_BR |
| ISSN | 1935-2727 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/45519 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Saxitoxina cianobacteriana | pt_BR |
| Subject in Portuguese | Morte de células neurais | pt_BR |
| Subject in Portuguese | Malformações cerebrais | pt_BR |
| Subject in Portuguese | Vírus da Zika | pt_BR |
| Title | The cyanobacterial saxitoxin exacerbates neural cell death and brain malformations induced by Zika virus | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pntd.0008060 | |
| Abstract | The northeast (NE) region of Brazil commonly goes through drought periods, which favor
cyanobacterial blooms, capable of producing neurotoxins with implications for human and
animal health. The most severe dry spell in the history of Brazil occurred between 2012 and
2016. Coincidently, the highest incidence of microcephaly associated with the Zika virus
(ZIKV) outbreak took place in the NE region of Brazil during the same years. In this work, we
tested the hypothesis that saxitoxin (STX), a neurotoxin produced in South America by the
freshwater cyanobacteria Raphidiopsis raciborskii, could have contributed to the most
severe Congenital Zika Syndrome (CZS) profile described worldwide. Quality surveillance
showed higher cyanobacteria amounts and STX occurrence in human drinking water supplies
of NE compared to other regions of Brazil. Experimentally, we described that STX doubled
the quantity of ZIKV-induced neural cell death in progenitor areas of human brain
organoids, while the chronic ingestion of water contaminated with STX before and during
gestation caused brain abnormalities in offspring of ZIKV-infected immunocompetent
C57BL/6J mice. Our data indicate that saxitoxin-producing cyanobacteria is overspread in
water reservoirs of the NE and might have acted as a co-insult to ZIKV infection in Brazil.
These results raise a public health concern regarding the consequences of arbovirus outbreaks
happening in areas with droughts and/or frequent freshwater cyanobacterial blooms. | pt_BR |
| Affilliation | Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Prof. Paulo de Góes. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Unidade Acadêmica de Garanhuns. PE, Brasil. | pt_BR |
| Affilliation | Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Cyanobacterial saxitoxin | pt_BR |
| Subject | Neural cell death | pt_BR |
| Subject | Brain malformations | pt_BR |
| Subject | Zika virus | pt_BR |
| e-ISSN | 1935-2735 | |
